The current invention relates to the method and apparatus to magnetically separate biological entities with magnetic labels from a fluid sample. The claimed methods separate biological entities with magnetic labels by using a magnetic device. The claimed methods further include processes to dissociate biological entities magnetic conglomerate after magnetic separation.

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.

Control over the wastewater purification can be achieved through controlling delivery of gas-dispersion return sludge solely to an aerobic reaction vessel. The gas-dispersion return sludge is created using pure oxygen or oxygen containing trace amounts of ozone as a reactive gas, which is blended with return sludge to create a mixture of gas and liquid, which is pressurized with an atomizer pump, and then at a pressure of not more than approximately 5.5 MPa, the mixture is passed through an atomizer which uses cavitation or ultrasound at a frequency of less than 12,000 KHz to instantly render the reactive gas in the mixture to an ultra-fine bubble state. A portion of the gas is placed into a dissolved state, reaching a state of supersaturation with a high DO value of 20-40 mg/l, and causing the remaining ultra-fine bubbles to create an ultra-fine bubble condition.

An ultrasonic mixing reactor configured for mixing of plant nutrients for greater absorption using cavitation. The reactor includes a venturi nozzle fluidly connected to a nozzle device having at least one annular shaped plate comprised of a plurality of apertures constructed and arranged to create cavitation. The nozzle device is fluidly coupled to a first ultrasonic reactor having a plurality of variable frequency ultrasonic transducers mounted within the first ultrasonic reactor for generating acoustic cavitation of the bulk mixed plant nutrients. The first ultrasonic transducer is fluidly connected to a second ultrasonic reactor having a plurality of variable frequency ultrasonic transducers mounted within the second ultrasonic reactor for generating acoustic cavitation of the bulk mixed plant nutrients. The second ultrasonic reactor discharge is fluidly coupled to a plate static mixer constructed and arranged to create hydrodynamic mixing.

A method of generating bubbles of a first fluid in a second fluid, the method comprising: flowing a stream of the second fluid through a microfluidic channel; injecting a stream of the first fluid into the microfluidic channel through an aperture such that bubbles of the first fluid form in the second fluid; and sonicating the microfluidic channel with ultrasound so as to cause the bubbles formed at the aperture to divide.

A bubble generation device includes: a metallic narrow tube (10) through which water passes; and a pump that pressure-feeds the water containing a gas component into the metallic narrow tube (10). A drawer (11) in which a path through which the water passes is narrower than the front and the rear thereof in the flow direction of the water is disposed on the inside of the metallic narrow tube (10). The drawer (11) has the rectangular cross section orthogonal to the flow direction. The gas component contained in the water is dissolved in the water by pressure-feeding the water to the drawer (11), bubbles are evolved due to a decrease in pressure in the drawer (11), turbulent flow is generated in the water in the drawer (11) to crush bubbles in the water by the shearing force thereof, and bubbles are crushed by a shock wave caused by transonic flow occurring in the water that has exited from the drawer (11).

Provided herein is an apparatus for manufacturing a drink. The apparatus for manufacturing a drink includes: an input unit receiving customer's order information; a material storing unit storing materials for manufacturing the drink therein; a drink manufacturing unit including a mixing tank receiving the materials stored in the material storing unit and mixing the received materials with each other; a drink outlet discharging the drink manufactured in the drink manufacturing unit; pipes forming connection paths for transferring the materials stored in the material storing unit to the drink manufacturing unit; valves formed in the pipes; a vacuum pump connected to the mixing tank of the drink manufacturing unit to generate vacuum in a material accommodating space formed in the mixing tank; and a controlling unit controlling the valves and the vacuum pump on the basis of the customer's order information input to the input unit to allow materials corresponding to a customer's order to be transferred to the mixing tank.

The invention relates to apparatus and a process for mixing a gas/vapour with a process liquid comprising a material and a carrier liquid. The apparatus comprises a passage (10) of polygonal cross section having an inlet (14), an outlet (16) for a process liquid comprising the material, and a nozzle (24) for introducing supersonic gas/vapour at a mixing zone (42) in a single plane.

A fluidic device includes a base structure, a wall structure, and a cover structure bounding a fluidic passage containing a functionalized active region of at least one bulk acoustic wave (BAW) resonator structure. One or more of the wall structure, the cover structure, or a portion of the base structure includes multiple features (e.g., protrusions and/or recesses) configured to interact with fluid flowing within the fluidic passage to promote mixing between constituents of the fluid. Methods for fabricating a fluidic device, as well as methods for biological or chemical sensing using a fluidic device, are further provided.