A system and method of wellbore operations that uses an eductor unit for introducing additives into a moving fluid stream to form a mixture. The mixture is used as a completion drilling fluid for drilling through plugs installed in a wellbore. Example additives include polymers, such as friction reducers, viscosifiers, potassium chloride, polysaccharide, polyacrylamide, biocides, lubricants, long chain polymer molecules, and the like. The fluid is primarily fresh water and/or brine water, and acts as a motive fluid in the eductor unit for drawing the additive into the eductor unit. Forming the mixture in the eductor unit which is injected into the wellbore.

A substrate processing apparatus includes a spray nozzle that allows a plurality of liquid droplets to collide with a substrate held by a spin chuck, a liquid piping that supplies a mixed liquid of water and a chemical liquid to the spray nozzle, a first flow control valve and a second flow control valve each of which changes the concentration of the chemical liquid in the mixed liquid, and a controller that causes the liquid piping to supply the mixed liquid having a concentration of the chemical liquid determined in accordance with a substrate to be processed.

Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.

An arrangement (2; 32) for adding a first fluid component into a flow system (1; 31), said arrangement comprising: a first pump (3; 33) provided in a first component adding fluid line (5; 35) which is connecting a first system fluid line (9; 39) of the flow system (1; 31) with a first fluid component source (7; 37) comprising the first fluid component to be added into the flow system; and a second pump (13; 43) provided in a second component adding fluid line (15; 45) connected in parallel with the first component adding fluid line (5; 35), said second component adding fluid line (15; 45) connecting the first system fluid line (9; 39) of the flow system with a first fluid component source (7; 47) comprising the first fluid component to be added into the flow system.

The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

To provide an emulsion preparation device capable of forming an emulsion in a chemical liquid of diverse composition and further realizing a relatively low sliding resistance. An emulsion preparation device (1) provided with a filter part (10), wherein: the filter part (10) is constructed from first and second, two mesh parts (31) and (33) and fibers (32); and the fibers (32) are loaded into a space (30) between the first mesh part (31) and the second mesh part (32).

A method for producing a single-phase phase-stable liquid is provided, in which, in an embodiment: in a first step, a lipophilic liquid is mixed with a hydrophilic liquid, so that a mixture of the liquids is obtained; in a second step, the static pressure of the mixture is brought below the vapor pressure of at least one of the liquids, so that cavitation bubbles occur, for example, as a result of what is known as hard cavitation; and in a third step, the cavitation bubbles are caused to implode, a single-phase phase-stable liquid being obtained.

An apparatus for generating one or several droplets of a first liquid in a second liquid immiscible with the first liquid includes a rotational body and a drive apparatus. The rotational body includes a fluid chamber, a fluid channel and a transition area. The transition area includes a first expansion area and a second expansion area. The drive apparatus is configured to provide the rotational body with such a rotation that the first liquid is supplied centrifugally to the fluid chamber and that centrifugally hydrodynamically induced pressure and lifting forces are caused due to the second expansion area, which cause a droplet break-off in the first liquid, such that a droplet of the first liquid embedded in the second liquid is generated.

An apparatus for preparing a water/diesel oil micro-emulsion comprises a diesel oil feeding unit (2), an emulsifying composition feeding unit (3), a water feeding unit (4), a mixing tank (5) in fluid communication with the diesel oil feeding unit (2), with the emulsifying composition feeding unit (3) and with the water feeding unit (4). A mixing device (22) is operatively connected to the mixing tank (5). The mixing device (22) comprises a duct (39) extending along a main direction (X-X) and presenting an inlet opening (40) and an outlet nozzle (41). A cone shaped septum (60) is placed in the duct (39), coaxial with respect to the main direction (X-X) and tapering towards the outlet nozzle (41). The cone shaped septum (60) is provided with a plurality of holes (65) made through its conical wall (63). A plurality of lamellae (76, 80) are arranged in at least a portion of the duct (39) placed downstream of the cone shaped septum (60). The plurality of lamellae (76, 80) divides said portion in a plurality of small chambers (77, 82) and are provided with through holes (78, 81). The holes (78, 81) and the small chambers (77, 82) delimit a labyrinth passageway for the liquid flowing through the duct (39) towards the outlet nozzle (41). The water/diesel oil micro-emulsion is obtained by recirculating a batch contained in the mixing tank (5) and comprising the diesel oil, the emulsifying composition and the water through a recirculation conduit and through the mixing device (22).

The present invention generally relates to microfluidic droplets and, in particular, to multiple emulsion microfluidic droplets. In one set of embodiments, multiple emulsion droplets are provided, where an inner shell of the droplet is relatively thin, compared to the outer shell (or other shells) of the droplet. For instance, in one set of embodiments, the inner droplet has an average thickness of less than about 1000 nm. In some cases, the inner shell may be rigidified, e.g., to form a gel or a polymeric layer. This may be useful, for example, for preventing coalescence of fluids within the microfluidic droplet. Other embodiments of the present invention are generally directed to methods of making such droplets, methods of using such droplets, microfluidic devices for making such droplets, and the like.