Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

The present invention provides a water-soluble composition including lysophosphatidylethanolamine, an organic solvent, a silane-based auxiliary agent, a surfactant, an antifreeze, and water. According to the water-soluble composition of the present invention, a lysophosphatidylethanolamine effective ingredient is not decomposed well even at a high temperature, and since the composition is stably dissolved in water when diluted in water before applied to crops, the stability of a water-soluble formulation is excellent. In addition, since surface tension is excellent, the composition may be uniformly distributed when treating fruits to show uniform ripening promoting effects of the fruits.

The present invention provides a water-soluble composition including lysophosphatidylethanolamine, an organic solvent, a silane-based auxiliary agent, a surfactant, an antifreeze, and water. According to the water-soluble composition of the present invention, a lysophosphatidylethanolamine effective ingredient is not decomposed well even at a high temperature, and since the composition is stably dissolved in water when diluted in water before applied to crops, the stability of a water-soluble formulation is excellent. In addition, since surface tension is excellent, the composition may be uniformly distributed when treating fruits to show uniform ripening promoting effects of the fruits.