Systems and methods are provided herein for transporting a biological sample. Systems and methods provided herein also include providing electrical monitoring of the donor tissue to track electrical activity during transportation. A potential QRS-like wave can be detected even in resting heart tissue to determine viability.

A biological specimen of a subject is handled and tracked for a procedure involving that specimen. Prior to initiation of the procedure, a first procedure data structure (PDS) is generated. The first PDS binds an identifier corresponding to the subject with an indicator of a procedure to be performed on the specimen and identifiers of a specimen container and a specimen holder that physically contacts the biological specimen, as well as a scheduled time for the procedure. A schedule of a plurality of PDSs including the first PDS, is displayed on a display device of a graphical user interface. Following initiation of the procedure, the first PDS is updated based on user input, and after the procedure, at least a portion of the first PDS, as updated, is stored in a database in conjunction with other PDSs respectively associated with other completed procedures.

A biological specimen of a subject is handled and tracked for a procedure involving that specimen. Prior to initiation of the procedure, a first procedure data structure (PDS) is generated. The first PDS binds an identifier corresponding to the subject with an indicator of a procedure to be performed on the specimen and identifiers of a specimen container and a specimen holder that physically contacts the biological specimen, as well as a scheduled time for the procedure. A schedule of a plurality of PDSs including the first PDS, is displayed on a display device of a graphical user interface. Following initiation of the procedure, the first PDS is updated based on user input, and after the procedure, at least a portion of the first PDS, as updated, is stored in a database in conjunction with other PDSs respectively associated with other completed procedures.

A portable cooler container system is described. The cooler container system includes a container body having a payload chamber and a temperature control system including a thermoelectric element, a hot side heat sink a cold side heat sink and a pump. The portable cooler container system further includes a conduit in thermal communication with a thermal mass, sensors, power storage elements and circuitry to control operation of the temperature control system.

An ex-vivo lung perfusion (EVLP) method may include ventilating a donor lung with a gas mixture that comprises carbon dioxide and circulating a perfusate through a perfusion circuit and the donor lung while ventilating the donor lung. The perfusion circuit does not have a membrane gas exchanger.

An ex-vivo lung perfusion (EVLP) method may include ventilating a donor lung with a gas mixture that comprises carbon dioxide and circulating a perfusate through a perfusion circuit and the donor lung while ventilating the donor lung. The perfusion circuit does not have a membrane gas exchanger.

Apparatus and methods for performing ex-vivo perfusion of an organ are disclosed. In one arrangement, an organ receiving unit (4) receives an ex-vivo organ and provides fluidic connections to a vasculature of the received organ. A first conduit system defines a perfusate flow circuit (21) including a flow path through the vasculature of the received organ. A perfusate pumping system (14) drives a circulatory flow of perfusate in the perfusate flow circuit and through the vasculature of the received organ. A second conduit system defines a dialysate flow circuit (22). A dialysate pumping system drives a circulatory flow of a dialysate in the dialysate flow circuit. A dialysis unit processes the perfusate using the dialysate, the dialysis unit comprising a membrane configured to contact the perfusate in the perfusate flow circuit on one side of the membrane and the dialysate in the dialysate flow circuit on the other side of the membrane. The membrane allows material to pass between the perfusate flow circuit and the dialysate flow circuit as a transmembrane flux.

Apparatus and methods for performing ex-vivo perfusion of an organ are disclosed. In one arrangement, an organ receiving unit (4) receives an ex-vivo organ and provides fluidic connections to a vasculature of the received organ. A first conduit system defines a perfusate flow circuit (21) including a flow path through the vasculature of the received organ. A perfusate pumping system (14) drives a circulatory flow of perfusate in the perfusate flow circuit and through the vasculature of the received organ. A second conduit system defines a dialysate flow circuit (22). A dialysate pumping system drives a circulatory flow of a dialysate in the dialysate flow circuit. A dialysis unit processes the perfusate using the dialysate, the dialysis unit comprising a membrane configured to contact the perfusate in the perfusate flow circuit on one side of the membrane and the dialysate in the dialysate flow circuit on the other side of the membrane. The membrane allows material to pass between the perfusate flow circuit and the dialysate flow circuit as a transmembrane flux.

Disclosed are systems and methods for the cryopreservation of biological samples. The system including a mixing device configured hold the biological sample and a cryoprotectant and mix the contents therein. The mixing device can include a basket that moves within mixing device to ensure efficient mixing of the cryoprotectant. The system further includes a cooling device to cool the sample and cryoprotectant. The method includes placing a biological sample within the basket, such that the container is subject to cooling by the cooling device. Subsequently, cryoprotectant is added while the cooling device cools the biological sample. During this process the basket is moved within the container.

Disclosed are systems and methods for the cryopreservation of biological samples. The system including a mixing device configured hold the biological sample and a cryoprotectant and mix the contents therein. The mixing device can include a basket that moves within mixing device to ensure efficient mixing of the cryoprotectant. The system further includes a cooling device to cool the sample and cryoprotectant. The method includes placing a biological sample within the basket, such that the container is subject to cooling by the cooling device. Subsequently, cryoprotectant is added while the cooling device cools the biological sample. During this process the basket is moved within the container.