A system for continuous processing of powder products includes a first inlet configured to input a first dry powder product, a second inlet configured to input a second dry powder product, and a dry powder mixing device that mixes the first dry powder product together with the second dry powder product to form a product mixture. An outlet dispenses the product mixture from the dry powder mixing device. A production machine is included and has a powder feed frame comprising a feed frame inlet connected to the outlet of the dry powder mixing device. The outlet of the dry powder mixing device is positioned at a lower level than the feed frame inlet. A product conveying device is connected between the outlet of the dry powder mixing device and the feed frame inlet to continuously convey the product mixture from the dry powder mixing device to the feed frame inlet.

Systems for a plastic pump/actuator capable of containing and pumping organic solvents and lubricants and having a more desirable lubricity within the system. The system has at least two cylinders, with plungers therein, oppositely disposed from each other and configured to operably connect to a pump.

A compounding platform including a compounding station having a user interface and a rotating device. The compounding platform including a chamber coupled to the compounding station. The rotating device is coupled to the chamber and configured to rotate the chamber relative to the compounding station. The compounding platform further including a consumable configured to be disposed within the chamber and including a plurality of ports and a bladder in fluid communication with the plurality of ports. The compounding platform has a first vial removably coupled to the consumable via a first port of the plurality of ports and including a diluent fluid, and a second vial removably coupled to the consumable via a second port of the plurality of ports and including a medicament. The compounding platform includes a plurality of valves configured to control fluid flow into and out of the bladder and corresponding to the plurality of ports.

Methods, spray devices, and kits for the in situ formation of silk fibroin fibers and/or aerosols are disclosed. Rapidly mixing a silk fibroin solution and a beta sheet initiation solution forms a mixed solution, which is rapidly expanded to form the silk fibroin fibers and/or aerosols. The beta sheet initiation solution includes a hygroscopic polymer having a molecular weight of between 7.5 kDa and 15.0 kDa. The rapid mixing and rapid expanding occur within one second of one another. Silk fibroin aerosols are formed when a molecular weight distribution of fragments in the silk fibroin solution is below an aerosol-fiber threshold. Silk fibroin fibers are formed when the molecular weight distribution is below the aerosol-fiber threshold.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.