A multi-parameter automatic blood cell counting device includes a basic information generating part, an immune cell subgroup detection part, an immunodynamic change analyzing part, a storage part, and display part. The basic information generating part acquires examination information about a blood count of blood components and a white blood cell image and CD classification analysis information about monoclonal antibodies that bind to lymphocyte surface antigens. The immune cell subgroup detection part detects information about immune cell subgroups required for analyzing an immune status of a subject based on the examination information and the CD classification analysis information. The immunodynamic change analyzing part identifies information about the change in immunodynamics of the subject based on the information detected by the immune cell subgroup detection part and the examination information and CD classification analysis information stored in the storage part, and displays an image of the identified information on the display part.

A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles.

In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images. The method also includes acquiring a second plurality of images of the same region of interest of the same capillary with an advanced optical device capable of resolving cellular structure of white blood cells and white blood cell subtypes and spatiotemporally annotating the second plurality of images with an indication of any white blood cell detected and/or a subtype of any white blood cell detected in the second plurality of images. The method also includes inputting the first plurality of images and annotated information from the first plurality of images and annotated information from the spatiotemporally annotated second plurality of images into a machine learning subsystem configured to determine a presence of white blood cells and/or the subtype of any white blood cells present in the one or more optical absorption gaps in the first plurality of images.

Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.

The present invention relates to methods for determining a blood gas parameter and/or a basic metabolic panel parameter in a blood sample comprising combining the blood sample with an anti-coagulant and an anti-platelet agent, and determining said blood gas parameter and/or parameter in the sample. In some aspects, the invention relates to determining said parameters in samples that have been subjected to pre-analytical stress.

Provided are a method and device for recognizing hook effect in immune turbidimetry, and a computer readable medium. This method generates a reaction curve using light signals measured in a predetermined time period by immune reaction of analyte in a sample, and uses distribution information of the reaction curve in the predetermined time period to determine whether the sample has hook effect. This method only uses measurement information of a small predetermined time period in entire reaction time to determine whether a sample has hook effect, and terminates the test in time, thus accelerating the speed of immune turbidimetry detection of samples with hook effect.

An inspection flow path device according to the present disclosure comprises: a first flow path device having a plate-like shape and including a pair of first surfaces located opposite to each other in a thickness direction and a first flow path located inside and including a first opening located in the pair of first surfaces and a branch flow path; and a second flow path device having a plate-like shape and translucency and including a pair of second surfaces located opposite to each other in a thickness direction and a second flow path located inside and including a second opening located in the pair of second surfaces; wherein one of the pair of first surfaces of the first flow path device is located on one of the pair of second surfaces of the second flow path device, and the first opening and the second opening are connected to each other.

A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.

A method for measuring concentrations of blood cell components is provided. The method comprises: obtaining a blood sample from a subject, the blood sample comprising at least one of red blood cells (RBCs), white blood cells (WBCs), and platelets (PLTs); mixing the blood sample with a non-lysing aqueous solution to form a sample mixture comprising a predetermined tonicity; passing the sample mixture through a flow cell; emitting light towards the flow cell; measuring at least one of an amount of light absorbed by the RBCs to obtain an RBC absorption value, an amount of light scattered by WBCs to obtain a WBC scatter value, and an amount of light scattered by PLTs to obtain a PLT scatter value; and determining a concentration of at least one of the RBCs, WBCs, and PLTs present in the sample mixture.

Systems and methods for providing clinical decision support information including one or more clinical acuity recommendations to a clinician is provided. The systems and methods can include obtaining one or more parameters associated with a blood sample obtained from an individual, the one or more parameters can include a monocyte distribution width (MDW) value. The systems and methods can also include comparing the MDW value with one or more predetermined criteria; and providing a clinical acuity recommendation at least partly in response to the comparing the MDW value with the one or more predetermined criteria.