In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images. The method also includes acquiring a second plurality of images of the same region of interest of the same capillary with an advanced optical device capable of resolving cellular structure of white blood cells and white blood cell subtypes and spatiotemporally annotating the second plurality of images with an indication of any white blood cell detected and/or a subtype of any white blood cell detected in the second plurality of images. The method also includes inputting the first plurality of images and annotated information from the first plurality of images and annotated information from the spatiotemporally annotated second plurality of images into a machine learning subsystem configured to determine a presence of white blood cells and/or the subtype of any white blood cells present in the one or more optical absorption gaps in the first plurality of images.

An apparatus for determining the mean corpuscular haemoglobin concentration (MCHC) in a whole blood sample includes a sample holder including an elongate sample chamber having an open end and a closed end. A holding member is adapted to receive and retain the sample holder. The holding member rotates may rotate about an axis of rotation. When the sample holder is received and retained by the holding member the sample chamber is substantially perpendicular to the axis of rotation. First and second light sources are positioned on one side of the sample holder and are configured to emit light in respective different frequencies. At least one light sensor is positioned on a second side of the sample holder, opposite from the first side, so that light from the light source may pass through the sample chamber, in at least one rotational position of the sample holder, and impinge on the light sensor.

A microfluidic device includes a substrate; a plurality of electrode channels, including a first electrode channel, a second electrode channel, a third electrode channel and a fourth electrode channel, each containing an electrode material to form an electrode; and a plurality of fluidic channels, including a first fluidic channel and a second fluidic channel, each being configured to form a fluid pathway for allowing a fluid sample to flow through and at least one of the first and second fluidic channels including a cell manipulation portion, the cell manipulation portion including a plurality of constriction portions. The first and second electrode channels are each coupled to the first fluidic channel and the electrodes of the first and second electrode channels and the third and fourth electrode channels are each coupled to the second fluidic channel and the electrodes of the third and fourth electrode channels.

A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.

A method for measuring concentrations of blood cell components is provided. The method comprises: obtaining a blood sample from a subject, the blood sample comprising at least one of red blood cells (RBCs), white blood cells (WBCs), and platelets (PLTs); mixing the blood sample with a non-lysing aqueous solution to form a sample mixture comprising a predetermined tonicity; passing the sample mixture through a flow cell; emitting light towards the flow cell; measuring at least one of an amount of light absorbed by the RBCs to obtain an RBC absorption value, an amount of light scattered by WBCs to obtain a WBC scatter value, and an amount of light scattered by PLTs to obtain a PLT scatter value; and determining a concentration of at least one of the RBCs, WBCs, and PLTs present in the sample mixture.

A sample classification device including a carrier, a first detection module, and a sample pipeline is provided. The first detection module includes a first light-emitting device, a second light-emitting device, and a first optical sensing device. The first light emitting device is located on the carrier and used to emit light of a first wavelength. The second light emitting device is located on the carrier and used to emit light of a second wavelength. The first wavelength is different from the second wavelength. The first optical sensing device is located on the carrier and between the first light emitting device and the second light emitting device. The sample pipeline is located above the carrier and passes above the first optical sensing device.

A blood sample collector can be used to collect a blood sample from a subject. The blood sample collector can be placed in a receptacle of a spectrometer to measure spectral data from the blood sample while the blood sample separates. The container may comprise a window to allow light such as infrared light to pass through the container, with the blood sample at least partially separating within the container between spectral measurements, which can provide improved accuracy of the measurements and additional information regarding the sample. The container may comprise an elongate axis and the container configured for placement in the spectrometer receptacle with the elongate axis extending toward a vertical direction in order to improve gravimetric separation of the blood sample. The spectrometer can be configured to measure the blood sample at a plurality of heights along the sample as the sample separates.

A particle separating and measuring device of the present disclosure includes: a first flow path device including a post-separation flow outlet through which a first fluid containing specific particles to be separated flows out; and a second flow path device on which the first flow path device is placed and including a first flow inlet through which the first fluid flows in, the first flow path device in which the post-separation flow outlet is arranged in a lower surface is placed on the second flow path device in which the first flow inlet is arranged in an upper surface of a first region, the post-separation flow outlet and the first flow inlet are connected so as to face each other, and a size of an opening of the first flow inlet is larger than a size of an opening of the post-separation flow outlet.

An erythrocyte differentiation monitoring apparatus includes a laser light source that radiates a pulsed laser beam in a hemoglobin absorption wavelength range onto a cell within a culture container, a probe that receives a photoacoustic wave emitted from the cell within the culture container as a result of the cell being irradiated with the pulsed laser beam emitted from the laser light source, and a processor that evaluates the progress of differentiation of the cell into an erythrocyte based on the intensity of the photoacoustic wave received by the probe.

There is provided a fine-particle sorting apparatus, including: a determination unit that performs sorting determination of a particle, the determination unit performing the determination using rule data defining, in accordance with a particle population to which a particle that is a sorting-determination target belongs and a particle population to which a different particle within a predetermined range around the particle belongs, a relationship between the particles, particle populations to which the particle that is a sorting-determination target and the different particle within the predetermined range may belong including the following particle populations of (a) a particle population of particles to be sorted, (b) a particle population of particles that are not to be sorted but are ignorable in the determination, and (c) a particle population of particles that are neither the particles to be sorted nor the ignorable particles, the ignorable particles including red blood cells.