A reagent container is disclosed that is installed in an analyzer for use and stores a reagent supplied to the analyzer via an aspiration tube. The reagent container includes a container body. The container body includes a tubular member with an opening into which the aspiration tube is inserted from above, and a bag-shaped member joined to the tubular member and storing the reagent. The container body comprises a penetration prevention member that prevents a tip of the aspiration tube 90 inserted through the opening from penetrating the container body.

A sample analyzer with an optical detection device and a sample analysis method of the sample analyzer are disclosed. The optical detection device includes a fluid chamber, a light source and a light detector. The fluid chamber includes an illumination zone. An analyte flows through the illumination zone so as to form a sample stream. The light source illuminates the illumination zone to excite cell articles, reacted with a reagent, of the sample stream to emit a light signal. The light detector detects the fluorescent lights and transforms it into an electric signal. The light detector can include a silicon photomultiplier.

The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.

The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.

A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.

Aspects of the invention include hematology analysis reagents, systems and methods that can be used to preserve blood cell morphology and integrity as well as provide sample integrity and optical clarity to facilitate optical analysis of blood samples. In some embodiments, the reagents include a non-phosphate organic buffer and a sphering surfactant. The pH and osmolality of the reagents may be adjusted to desired ranges. In addition, the reagents can be simply diluted with de-ionized water prior to use.

A sample analysis system and a sample management method are provided. The sample analysis system includes: one or more analysis devices configured to test a sample; a scanning component configured to scan the sample to obtain scanning information before testing the sample by the analysis devices; an image information obtaining component configured to acquire image information of a region in the sample containing a sample identifier; a processor configured to identify the sample identifier of the sample according to at least one of the scanning information or the image information of the sample. The system can obtain the sample identifier of a sample in two ways, thus improving the efficiency of sample test.

The present invention relates to a method of maturity classifying reticulocytes from a whole blood sample, comprising: staining the sample with a supravital agglutinating dyeing reagent or a fluorescent agglutinating dye; illuminating the stained sample with a light beam to detect reticulocytes; determining for each reticulocyte the parameters of (i) a fraction (Λ) of the reticulum area (Ar) to the whole cell area (Ac); and (ii) a fraction (Γ) of the perimeter of the reticulum (Ur) to the reticulum area (Ar); and maturity classifying a reticulocyte into 1 of 4 major maturity classes according to the values determined for Λ and Γ.

The disclosure provides a sample testing method and a sample analyzer, the method including: providing a sample and a reagent, the reagent including at least two fluorescent dyes for staining particles in the sample, wherein an absolute value of a difference between wavelengths corresponding to peaks of emission spectra of the two fluorescent dyes is greater than 30 nanometers and less than 80 nanometers, and an overlap between the emission spectra of the two fluorescent dyes is not greater than 50%; mixing the sample and the reagent to form a sample solution; flowing the sample solution in a flow cell in a single test, irradiating the particles flowing in the flow cell using light with a single wavelength; detecting at least fluorescence signals generated by the particles; and obtaining a test result of the sample based on at least the fluorescence signals.

A sample analyzer with an optical detection device and a sample analysis method of the sample analyzer are disclosed. The optical detection device includes a fluid chamber, a light source and a light detector. The fluid chamber includes an illumination zone. An analyte flows through the illumination zone so as to form a sample stream. The light source illuminates the illumination zone to excite cell articles, reacted with a reagent, of the sample stream to emit a light signal. The light detector detects the fluorescent lights and transforms it into an electric signal. The light detector can include a silicon photomultiplier.