A breath testing apparatus is provided to test hydrogen sulfide and other parameters in exhaled breath of a patient. A patient sample input for receiving exhaled breath from a patient is provided, in addition to an atmospheric input for receiving atmospheric air. A valve is coupled to said patient sample input and said atmospheric input, and first and second pathways are provided from said valve to a hydrogen sulfide sensor block and a second sensor block.

The disclosure provides a preparation method for a graphene material-based resistive gas sensor array and an application method thereof. The preparation method includes: adding a metal salt solution to a graphene oxide solution to obtain a mixed suspension, adjusting a pH of the mixed suspension and dispersing the mixed suspension under ultrasound, incubating the mixed suspension on a shaker, then washing it with deionized water followed by dispersing it in a deionized water to obtain metal ion-induced graphene oxide self-assembled suspension, and preparing a plurality of parts of the suspension by varying the preparation conditions; and adding the plurality of parts of metal ion-induced graphene oxide self-assembled suspension respectively to fingers of a multi-site interdigitated electrode array, and drying naturally, reducing the plurality of parts of the suspension at 60 to 120° C. for 3 to 30 min. The disclosure achieves uniform loading of a graphene material on a substrate.

Ultrasensitive, ultrathin thermodynamic sensing platforms for the detection of chemical compounds at trace levels are disclosed. Embodiments of the ultrathin sensor comprise substrate, adhesion, microheater, and catalyst layers. A sensor array may include a plurality of sensors each having a different catalyst. When a sensor array exposed to an analyte, each of the various sensors of the array may experience an endothermic reaction, an exothermic reaction, or no reaction. A comparison of the reaction results to data comprising previously-obtained reaction results may be used to determine information on the analyte. Advantageously, these ultrathin vapor sensors utilize less power and provide greater sensitivity, and may be used to detect and identify analytes at the PPT level. Specialized sensors configured to detect analytes falling into a certain category (e.g., explosives, drugs and narcotics, biomarkers, etc.) are disclosed, as well as general purpose sensors capable of detecting analytes from a plurality of categories.

The disclosure pertains to a system 100 and method for collecting and measuring particles in exhaled air. The system 100 is arranged to allow for examination of the full or substantially the full volume of each exhalation of a subject.

In order to objectively grasp a stress state of a user and to prevent postpartum depression, biological gas information is acquired via a network, where the biological gas information indicates a concentration of benzothiazole of the user and is obtained by a sensor that detects benzothiazole released from a skin surface of the user. From a memory storing information including an upper limit of a normal range of the concentration of benzothiazole per unit period, the information indicating the upper limit of the normal range is read out. When a frequency in the unit period with which the concentration of benzothiazole of the user exceeds the upper limit of the normal range is determined to have an increasing tendency based on the biological gas information obtained during a pregnancy period of the user, the information related to stress of the user is output to an information terminal of the user.

A breath analyte capture device includes a breath input port into which a user exhales a breath sample, and a cartridge insertion port for receiving a disposable cartridge containing an interactant. During exhalation of a breath sample, at least a portion of the breath sample is routed through the cartridge such that the analyte (such as breath acetone) is captured by the interactant. In some embodiments, the concentration of the analyte in the breath sample is measured by monitoring a chemical reaction that occurs in the disposable cartridge. The chemical reaction may be monitored by illuminating the cartridge at each of multiple light wavelengths while measuring reflected light.

The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).

A method for synchronizing data for gas samples with volatile organic compounds. The data includes chromatographic data indicative of molecule retention times. The method includes identifying or selecting marker molecules and clustering the plurality of gas samples into a plurality of clusters according to a clustering criterion. Next, a first correction of retention time deviations is performed on the data for the gas samples between clusters by using the marker molecules as anchor points to provide a coarse reduction of retention time deviations between the data. Finally, a second correction of retention time deviations is performed on the data, so as to further reduce retention time deviations between the data. The method reduces significant retention time deviations to allow, e.g., breath sample fingerprints obtained by different equipment at different times to be compared in one database for use on a digital platform.

A hybrid gas sampling device can combine the functionality of both whole air and sorbent based samplers. The sampling device can be used for collecting light to very heavy organic compounds, for subsequent thermal desorption into a GC or GCMS for quantitative measurement. The sampling device isolates collected samples of gas phase matrices in a sample vessel, provided with sorbent elements from a removable sample extraction device. The sampling device is operated by drawing a vacuum on the chamber through the sample extraction device after sampling, and then completing the extraction of the heavier organic compounds using a static, diffusive extraction under vacuum to allow optimal deposition of the heavier compounds on the sorbent. The vacuum container is cooled to draw any excess water back into the container, thereby dehydrating attached sorbent element(s) in preparation for thermal desorption into a GC or GCMS, eliminating interferences in the MS analyzer.

A high throughput method for label-free, noncontact, noninvasive, and nondestructive detection of at least one virus infected or virus free individual from at least one tested individual is provided. The method includes collecting a sample from exhaled breath of a subject for analysis of the sample. The collecting includes the subject exhaling into at least one sampler and collecting aerosols and/or any airborne compound from the exhaled breath by passing the exhaled breath through a metamaterial membrane within the sampler. The metamaterial membrane is arranged transverse to a flow of exhaled breath through the sampler. The method further includes analyzing the sample for detection of at least one virus infected individual from at least one tested individual.