A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

A particle occurrence sensing circuit for microfluidic particle sensing includes a set of particle event indicators, each of which includes: a Coulter counter having a sensing electrode exposable to a fluid within a microfluidic channel and configured for providing a particle sensing signal; an input stage configured for providing an extracted particle sensing signal; and a particle event detector configured for providing a set of particle event occurrence signals. Each of the set of particle event occurrence signals indicates a sensed occurrence of a particle greater than or equal to a given reference particle size during fluid flow through the microfluidic channel to which the sensing electrode is exposed. The particle event detector includes a successive approximation (SA) analog-to-digital converter (ADC) configured for generating a plurality of reference particle size threshold values and successively comparing the extracted particle sensing signal amplitude with reference particle size threshold values.

A method for processing a substrate by using fluid flowing through a particle detector is provided. The particle detector is utilized to detect nano-particles contained in fluid. The particle detector includes a substrate and a pair of sensing electrodes disposed on the substrate. The substrate includes nano-pores, wherein the pore size of the nano-pores is greater than the particle size of the nano-particles, allowing the nano-particles contained in the fluid passing through the nano-pores. The pair of sensing electrodes are positioned adjacent to at least one of the nano-pores.

A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

A nanopore device measures a current signal Is that flows through the nanopore device, which has an aperture and an electrode pair. A transimpedance amplifier converts the current signal Is into a voltage signal Vs. A voltage source is configured to apply a DC bias voltage Vb across the electrode pair in a normal measurement mode, and to apply a calibration voltage Vcal across the electrode pair in a calibration mode. In the calibration mode, at least one circuit constant of a measurement apparatus is calibrated based on the output signal Vs of the transimpedance amplifier and the calibration voltage Vcal.

A nanopore device includes a pore and an electrode pair. A current measurement unit applies a bias voltage that corresponds to a voltage setting command across an electrode pair and generates digital current data that corresponds to a current signal that flows through the nanopore device. A data processing apparatus generates the voltage setting command, acquires the current data and voltage data including information with respect to the waveform of the bias voltage Vb in a form in which they are associated on the time axis, and judges the kind of particles stored in the nanopore device based on the current data and the voltage data.

A particle analysis device includes an upper liquid space in which a first liquid is stored, a lower liquid space in which a second liquid is stored, a connection pore connecting the upper liquid space to the lower liquid space, and first to fourth holes. Each of the first to fourth holes has an opening that opens at a top surface of the particle analysis device. The first and second holes extend to the upper liquid space. The third and fourth holes extend to the lower liquid space. A first electrode applies an electric potential to the first liquid in the upper liquid space through the first hole, and a second electrode applies an electric potential to the second liquid in the lower liquid space through the third hole. The opening of at least one of the first hole and the second hole has an area that is greater than the rest of the hole. The opening of at least one of the third hole and the fourth hole has an area that is greater than the rest of the hole.

A method for processing a substrate by using fluid flowing through a particle detector is provided. The particle detector is utilized to detect nano-particles contained in fluid. The particle detector includes a substrate and a pair of sensing electrodes disposed on the substrate. The substrate includes nano-pores, wherein the pore size of the nano-pores is greater than the particle size of the nano-particles, allowing the nano-particles contained in the fluid passing through the nano-pores. The pair of sensing electrodes are positioned adjacent to at least one of the nano-pores.

The present disclosure relates to a sensor arrangement (1) for analyzing substances in a material, comprising a substrate (2), a first reception area (5) for receiving a first material, an electronic component sensor (3), a test area (4) that is in contact with the electronic component sensor (3), and a control device (10). The first reception area (5) and the test area (4) are arranged on the substrate (2). The control device (10) is configured for controlling the first reception area (5) and/or the test area (4) to move a portion of the first material from the first reception area (5) into the test area (4). Further, the present disclosure relates to a method for operating such a sensor arrangement (1).

A particle detector for detecting nano-particles contained in fluid is provided. The particle detector includes a substrate and at least one pair of sensing electrodes disposed on the substrate. The substrate includes nano-pores, wherein the pore size of the nano-pores is greater than the particle size of the nano-particles, allowing the nano-particles contained in the fluid passing through the nano-pores. The at least one pair of sensing electrodes are positioned adjacent to at least one of the nano-pores.