A system and method for determining an incapacitation state of an occupant is disclosed. The system may include an audio sensor configured to sense sensor data including active speaker audio of an occupant of two or more occupants. The system may also include a controller communicatively coupled to the audio sensor and configured to execute program instructions causing the processors to identify the active speaker, assign an identification code, receive a trigger, query a call response module, determine the occupant state, and direct aircraft operations based on the occupant state.