Provided is a syringe with which it is possible to hold with greater stability a liquid inside the barrel while maintaining the slidability and air-tightness between the barrel and the gasket without requiring fixation of silicone oil, and which is excellent in terms of accuracy of visual inspection. The syringe has a resin barrel, a gasket slidably inserted inside the barrel, a plunger attached to the gasket, and a silicone film obtained by applying silicone oil having a kinematic viscosity of 500 to 10,000 cSt over the inner peripheral surface of the barrel in an amount of 5 to 50 g per 1 cm.sup.2 of area.

An isolator system for filling a container with a liquid, the isolator system comprises a filling module having a filling station for filling the container with the liquid, a stopper placing station for placing a stopper on the filled container, and a plurality of handling devices for handling the container within the filling module; a first transfer station for transferring the container to be filled into the filling module; a second transfer station for transferring the filled container out of the filling module; and a control device. The present application also discloses a transfer station for transferring a container and several methods.

An isolator system for filling a container with a liquid, the isolator system comprises a filling module having a filling station for filling the container with the liquid, a stopper placing station for placing a stopper on the filled container, and a plurality of handling devices for handling the container within the filling module; a first transfer station for transferring the container to be filled into the filling module; a second transfer station for transferring the filled container out of the filling module; and a control device. The present application also discloses a transfer station for transferring a container and several methods.

An administration packaging and method for its production. The administration packaging having a bottom part and a cover which are formed of multi-layer films.

The invention relates to a closing apparatus for closing pharmaceutical containers, having a closing tool for joining a closure element to a pharmaceutical container (68), having a fluid unit for applying at least one gaseous fluid to the container, the fluid unit having at least one filter (64, 66), wherein the closing apparatus has a tool receptacle (14) and a tool unit (18), wherein the tool unit (18) is designed as a module which is repeatedly detachable from and connectible to the tool receptacle (14) by means of a coupling device (16) and which comprises the closing tool, the fluid unit and the at least one filter (64, 66).

A machine for coupling a plunger rod to a syringe assembly may include a carriage including a cradle having a seat portion sized to receive a syringe assembly and an aperture portion disposed above the seat portion and sized to receive a plunger rod. An actuating device may be operatively coupled to the carriage and adapted to move the cradle from a first position to a second position to couple the plunger rod to the syringe assembly. The carriage may be selected from separate and interchangeable first and second carriages, wherein the first carriage includes a cradle adapted to receive a syringe assembly of a first size and the second carriage including a cradle sized to receive a syringe assembly of a second size that is different from the first size.

The invention relates to a system (10) for transporting loose sterile closure elements (12) from the surroundings (14) of an isolator (16) into an interior (18) of the isolator, comprising a container (24) for storing a stock quantity of closure elements in the surroundings of the isolator, an isolator opening (20) and a collecting device (56) for collecting the closure elements and for providing the closure elements in the interior of the isolator, with a metering device (46) for controlling a target quantity of closure elements to be transported from the container through the isolator opening and into the collecting device.

An apparatus for closing pharmaceutical containers with closure elements, and a system for processing pharmaceutical containers. The closure elements include a first face and a second face. The apparatus includes a feed unit with a feed path in which closure elements can be fed separately without contacting the first face; a receiving body with a receptacle for the closure element, the closure element being transferrable from the feed path into a receiving position in the receptacle; and a device for turning the receiving body from an initial position into an end position and transferring the closure element from the receiving position into a placed position in which the closure element is positioned on the container or at a distance to the container such that the first face points in the direction of the container interior.

A system for high-speed filling and plugging, includes a conveying device, a plug delivering device, a filling device, a first plugging device, a second plugging device and a rubber plug transport device which is used for transferring a rubber plug to the first plugging device and the second plugging device. The filling device, the first plugging device, the second plugging device, the rubber plug transport device and the plug delivering device are sequentially arranged along the conveying device. The rubber plug transport device includes a first plugging plate provided with a first rubber plug positioning channel, a second plugging plate provided with a second rubber plug positioning channel, and an eccentric shaft assembly used for driving the first plugging plate and second plugging plate to rotate so as to adjust the distance between the first rubber plug positioning channel and the second rubber plug positioning channel.

The present invention involves a sterilizable vacuum chamber that provides for sealing a pharmaceutical fluid into a plurality of containers, the chamber comprising a vertically movable container nest holder for holding a container nest bearing a plurality of pharmaceutical containers filled with a pharmaceutical fluid, a container closure nest holder for holding a closure nest bearing a plurality of corresponding container closures and for locating a closure vertically above each corresponding container, a ram for vertically moving the container nests to engage the containers with corresponding closures, and an elastically deformable closure nest restraining element disposed on an opposing side of the closure nest from the container nest. A method is provided for sealing the pharmaceutical fluid into the containers. The method comprises the closure nest restraining element acting on the closure nest to oppose any vertical upward motion of any of the plurality of containers after the engaging of the containers with the closures.