An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.

A device (10) for weighing individual containers (14) arranged in a nest (12), wherein the containers (14) are formed with a bottom region (16) and a lid region (18) and the device (10) includes at least one weighing device (20) with at least one load cell (19) and with at least one weighing receptacle (22), and an arrangement unit (28). The weighing receptacle (22) and the arrangement unit (28) are arranged movable relative to each other in order to be able to move a container (14) arranged in the nest (12), which is arranged in the arrangement unit (28), completely out of the nest (12). The disclosure also relates to a set comprising such a device (10) and to a method for weighing individual containers (14) arranged in a nest (12).

A device for preparing radioactive solutions, in particular radiopharmaceutical solutions, including: a movable support block with at least two cells capable of accommodating a vial; and a shielded covering, including a side wall surrounding the periphery of the support block and an upper wall covering the upper face of the support block, an opening being provided in the upper wall of the covering. A means for driving the support block is configured to selectively displace the support block into positions, referred to as working positions, in which a given cell is aligned with the opening to allow access to the cell from the outside of the covering. The support block is configured such that it can be further brought to a position, referred to as closing position, in which the opening is sealed by a shielded element carried by the support block.

A filling device for filling nested containers, which are arranged in at least one row in a nest and are conveyable by means of a conveying device, having a filling station for simultaneously filling the containers of one row, having at least one weighing station for weighing a row of containers, having a first gripping device for simultaneously removing a row of containers to be filled and for transferring said containers to a first weighing station of the at least one weighing station and for transferring the weighed containers from the at least one weighing station back into the nest or into a different nest. The filling device additionally comprises a second gripping device, for simultaneously removing the row of filled and weighed containers and for transferring said containers to the first weighing station or to a second weighing station of the at least one weighing station and for transferring the row of filled and twice weighed containers from the at least one weighing station back into the nest or into a different nest.

The invention relates to chemical and pharmaceutical industry, in particular to technologies of obtaining sterile drugs, drug substances and cosmetic products used in the form of solutions or emulsions, and comprising poloxamer. The thermal method for sterilizing aqueous poloxamer solutions is provided, the method including: dissolving a poloxamer in water for injection; performing the sterilizing filtration of the aqueous poloxamer solution simultaneously with filling sterile containers with the filtered poloxamer solution; sealing the containers containing the poloxamer solution; applying a thermal sterilization with steam under pressure to the containers containing the poloxamer solution, and cooling them, wherein the thermal sterilization of the containers containing the poloxamer solution with steam under pressure is performed under the pressure between 82.4 and 107.8 kPa.

A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

A labelling device for syringes for pharmaceutical products includes a carousel that holds and transports syringes, a syringe labelling station, a syringe handler, a camera for detecting the position of the marker scale of the syringes. The syringe labelling station includes an arm responsible for holding the label by a suction system and two articulated gates arranged such that when the syringe passes therethrough, the gates apply pressure over the body of the syringe in such a way that the label is affixed uniformly over the body.

A product bag includes a bladder and an elongated filtration device. The bladder includes opposing first and second film layers defining a product chamber. The first and second film layers are sealed together along a perimeter seal extending along at least a portion of a perimeter of the bladder. The elongated filtration device includes a housing, a filtration membrane disposed in the housing, an inlet adapted for receiving a fluid to be filtered, and an outlet in fluid communication with the product chamber. A majority of the elongated filtration device is embedded between the first and second film layers of the perimeter seal of the bladder to provide for a compact form factor.

A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.