A method for producing sterile solution product bags includes positioning a manifold assembly onto a filling machine. The manifold assembly includes a plurality of bags, a first filter, and a connection line in fluid communication with the first filter. Each of the plurality of bags includes a bladder and a stem in fluid communication with the bladder and with the connection line. The method includes activating a pump and at least partially filling one or more of the bladders by pumping fluid through the feed line, the first filter, and the connection line. The method includes sealing the stem of each of the filled product bags at a location between the connection line and the bladder, thereby creating one or more at least partially filled and sealed product bags. The method includes separating each of the at least partially filled and sealed product bags from the connection line.

A system for filling a blow-fill-seal (BFS) container is provided. The system includes a first fluid circuit constructed to selectively deliver a purge fluid to an open BFS container. A second fluid circuit selectively delivers a product to the open BFS container. A third fluid circuit, having a vent line in fluid communication with the open BFS container and to the ambient, directs a bulk fluid comprising at least the purge fluid from the container when the purge fluid is introduced into the BFS container. The second circuit selectively delivers product when the first fluid circuit selectively does not deliver the purge fluid, and the second circuit selectively does not deliver product when the first circuit selectively delivers the purge fluid.

The present invention provides a measurement method, a measurement device, and a program capable of non-destructively measuring a volume of an aqueous solution of a drug in each needle-like recess of a mold with high accuracy. A measurement method according to a preferred embodiment of the present invention includes a measurement wave intensity acquisition step of acquiring, for each needle-like recess, an intensity of a measurement wave transmitted through a drug in a needle-like recess, absorbed by the drug by an amount according to a distance by which the measurement wave is transmitted through the drug, and emitted from the drug; and a volume acquisition step of acquiring a volume for each needle-like recess on the basis of the intensity of the measurement wave for each needle-like recess acquired in the measurement wave intensity acquisition step.

A machine for coupling a plunger rod to a syringe assembly may include a carriage including a cradle having a seat portion sized to receive a syringe assembly and an aperture portion disposed above the seat portion and sized to receive a plunger rod. An actuating device may be operatively coupled to the carriage and adapted to move the cradle from a first position to a second position to couple the plunger rod to the syringe assembly. The carriage may be selected from separate and interchangeable first and second carriages, wherein the first carriage includes a cradle adapted to receive a syringe assembly of a first size and the second carriage including a cradle sized to receive a syringe assembly of a second size that is different from the first size.

A closure processing equipment for closing openings of a number of containers includes a number of stopper members, a container holder and a set of compensation structures. Each of the stopper members is made of an elastic material, has a plug portion configured to fit into an opening of one of the number of containers and has a cover portion configured to abut a boundary surface adjacent to the opening of the one of the number of containers. The container holder has a number of container seats each configured to receive one of the number of containers in a predefined position. Each compensation structure of the set of compensation structures is configured to compensate a container manufacturing dimension tolerance. The set of compensation structures includes diverse compensation structures to compensate different container manufacturing dimension tolerances.

A labelling device for syringes for pharmaceutical products includes a carousel that holds and transports syringes, a syringe labelling station, a syringe handler, a camera for detecting the position of the marker scale of the syringes. The syringe labelling station includes an arm responsible for holding the label by a suction system and two articulated gates arranged such that when the syringe passes therethrough, the gates apply pressure over the body of the syringe in such a way that the label is affixed uniformly over the body.

A packaging apparatus is provided for holding a sterile product. In one aspect, a secondary packaging holder is configured with a base and a receiving portion to receive and irreversibly hold a primary packaging holder. The secondary packaging holder can have a substantially planar wall configured to affix an identifying label thereto. The secondary packaging holder can be configured to snap fit to a neck of the primary packaging holder to hold the primary packaging holder such that a portion of the primary packaging holder is exposed outside of the secondary packaging holder based on a height relationship between the secondary packaging holder and the primary packaging holder.

A method for the production and filling of an application package for a liquid pharmaceutical product. A thermoforming film made of thermoplastics laminated together is heated in order to plasticize the thermoforming film at least in partial areas. The plasticized areas are thermoformed in a mold in order to form a chamber for the liquid pharmaceutical product and a tube-shaped application duct opening into this chamber, with the chamber and the application duct being enclosed by a non-thermoformed, essentially flat bonding area of the thermoforming film. The liquid pharmaceutical product is filled into the chamber, and the chamber and the application duct are sealed by covering the thermoformed and filled thermoforming film with an essentially flat covering film. The covering film is directly bonded to the bonding area of the thermoforming film by thermal ring sealing, enclosing the chamber and the application duct.

A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

A machine for the preparation of medical product includes a device for loading bags of medical product into the machine. The device includes a shaft with the ability to rotate and two or more adaptors for housing injection points of bags of medical product arranged on the shaft. The rotation of the shaft causes the adaptors arranged on the shaft to rotate. Two stops define a position for loading bags by an operator and an operating position of the machine.