A doser mechanism includes a cylindrical shell, an auger conveyor, and a check valve. The cylindrical shell includes a hollow cylinder and an end plate. The hollow cylinder at least partially defines an internal enclosure extending between first and second ends of the hollow cylinder, a first opening at the first end, and a second opening through a thickness of the hollow cylinder. The end plate covers the second end. The auger conveyor includes an auger at least partially extending through the internal enclosure through the first end. The check valve has a valve member configured to selectively cover the second opening. The check valve may cause the valve member to move between a rest position and an open position to cover or expose the second opening in response to a magnitude of a force applied to the valve member from the internal enclosure through the second opening.

A doser mechanism includes a cylindrical shell, an auger conveyor, and a check valve. The cylindrical shell includes a hollow cylinder and an end plate. The hollow cylinder at least partially defines an internal enclosure extending between first and second ends of the hollow cylinder, a first opening at the first end, and a second opening through a thickness of the hollow cylinder. The end plate covers the second end. The auger conveyor includes an auger at least partially extending through the internal enclosure through the first end. The check valve has a valve member configured to selectively cover the second opening. The check valve may cause the valve member to move between a rest position and an open position to cover or expose the second opening in response to a magnitude of a force applied to the valve member from the internal enclosure through the second opening.

Embodiments provide apparatus, systems and methods for automated filling of syringes. One embodiment of an apparatus for filing of a plurality of syringes (POS) comprises a housing, a push-pull mechanism (PPM) disposed within the housing, a syringe locking mechanism (SLM) coupled to the housing, a manifold engagement fixture (MEF) mounted on the housing, a processor and a touch screen (TS) positioned on the housing. The PPM engages the POS and independently advances or retracts a plunger of each syringe. The SLM engages and constrains the POS to substantially prevent syringe motion during filling. The MEF includes a cam mechanism having a lever means (e.g., a lever arm) and is configured to detachably engage halves of a multi-port fluid manifold and bring them together to form a fluidic seal by movement of the lever arm. The TS allows for haptic input and display of information associated with operation of the apparatus.

Embodiments provide apparatus, systems and methods for automated filling of syringes. One embodiment of an apparatus for filing of a plurality of syringes (POS) comprises a housing, a push-pull mechanism (PPM) disposed within the housing, a syringe locking mechanism (SLM) coupled to the housing, a manifold engagement fixture (MEF) mounted on the housing, a processor and a touch screen (TS) positioned on the housing. The PPM engages the POS and independently advances or retracts a plunger of each syringe. The SLM engages and constrains the POS to substantially prevent syringe motion during filling. The MEF includes a cam mechanism having a lever means (e.g., a lever arm) and is configured to detachably engage halves of a multi-port fluid manifold and bring them together to form a fluidic seal by movement of the lever arm. The TS allows for haptic input and display of information associated with operation of the apparatus.

A filler assembly comprising a pouch preheat zone, a pouch sterilization zone, and a pouch flush zone. The preheat zone includes a preheat nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and a preheat vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch sterilization zone includes a sterilization nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a sterilization vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch flush zone includes a pouch flush nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a pouch flush vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum.

A filler assembly comprising a pouch preheat zone, a pouch sterilization zone, and a pouch flush zone. The preheat zone includes a preheat nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and a preheat vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch sterilization zone includes a sterilization nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a sterilization vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch flush zone includes a pouch flush nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a pouch flush vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum.

A doser mechanism includes a cylindrical shell, an auger conveyor, and a check valve. The cylindrical shell includes a hollow cylinder and an end plate. The hollow cylinder at least partially defines an internal enclosure extending between first and second ends of the hollow cylinder, a first opening at the first end, and a second opening through a thickness of the hollow cylinder. The end plate covers the second end. The auger conveyor includes an auger at least partially extending through the internal enclosure through the first end. The check valve has a valve member configured to selectively cover the second opening. The check valve may cause the valve member to move between a rest position and an open position to cover or expose the second opening in response to a magnitude of a force applied to the valve member from the internal enclosure through the second opening.

A doser mechanism includes a cylindrical shell, an auger conveyor, and a check valve. The cylindrical shell includes a hollow cylinder and an end plate. The hollow cylinder at least partially defines an internal enclosure extending between first and second ends of the hollow cylinder, a first opening at the first end, and a second opening through a thickness of the hollow cylinder. The end plate covers the second end. The auger conveyor includes an auger at least partially extending through the internal enclosure through the first end. The check valve has a valve member configured to selectively cover the second opening. The check valve may cause the valve member to move between a rest position and an open position to cover or expose the second opening in response to a magnitude of a force applied to the valve member from the internal enclosure through the second opening.

A filler assembly comprising a pouch preheat zone, a pouch sterilization zone, and a pouch flush zone. The preheat zone includes a preheat nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and a preheat vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch sterilization zone includes a sterilization nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a sterilization vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch flush zone includes a pouch flush nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a pouch flush vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum.

A filler assembly comprising a pouch preheat zone, a pouch sterilization zone, and a pouch flush zone. The preheat zone includes a preheat nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and a preheat vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch sterilization zone includes a sterilization nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a sterilization vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch flush zone includes a pouch flush nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a pouch flush vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum.