A tube holder is disclosed for carrying a tube to multiple processing stations of a tube filling machine. In one non-limiting embodiment, the tube holder includes a body comprising a receptacle configured for retaining a tube. The tube includes a dispensing end and an opposite open end for filling a cavity therein with a product. A retractable tube shaping device is movably disposed in the tube holder. The shaping device is movable between an extended position and a retracted position. When the shaping device is in the extended position, the shaping device engages the tube proximate to the open end and removes ovality which might interfere with the tube filling operation. In various embodiments, the shaping device comprises a plurality of vertically retractable straightening elements that engage the sidewalls of the tube to ensure circularity of the open tube end.

The invention relates to a tube with an application tip for liquid or pasty material, in particular pharmaceutical. The tube has a tube body with an end which can be closed or has already been closed and with an outlet end. The outlet end of the tube has a tube neck with an outlet opening. Furthermore, the tube according to the invention has an application tip which is elongated in the longitudinal direction of the tube, is connected to the outlet end of the tube, and has an inner channel which connects an inlet opening and an application opening. A closure which closes the application opening is moulded onto the application opening of the application tip. The application tip has a gripping means.

A reservoir for a nebulizer, and a nebulizer with a reservoir in which, to avoid undesirable rises in pressure, a fluid chamber of the reservoir is pre-collapsed and filled with an initial amount of fluid which is less than the maximum volume of the fluid chamber. Preferably, before being filled, the fluid chamber is compressed and/or expanded by means of gas to a defined volume which is less than the maximum volume of the fluid chamber.

A method of filling a container (30) with a liquid content (31), by ejecting a multilayer filler that includes a core layer of the fluid content and an outermost layer of a liquid while forming a film of the liquid between the inner wall of the container and the liquid content.

The invention relates to a tube with an application tip for liquid or pasty material, in particular pharmaceutical. The tube has a tube body with an end which can be closed or has already been closed and with an outlet end. The outlet end of the tube has a tube neck with an outlet opening. Furthermore, the tube according to the invention has an application tip which is elongated in the longitudinal direction of the tube, is connected to the outlet end of the tube, and has an inner channel which connects an inlet opening and an application opening. A closure which closes the application opening is moulded onto the application opening of the application tip. The application tip has a gripping means.

The invention relates to a tube with an application tip for liquid or pasty material, in particular pharmaceutical. The tube has a tube body with an end which can be closed or has already been closed and with an outlet end. The outlet end of the tube has a tube neck with an outlet opening. Furthermore, the tube according to the invention has an application tip which is elongated in the longitudinal direction of the tube, is connected to the outlet end of the tube, and has an inner channel which connects an inlet opening and an application opening. A closure which closes the application opening is moulded onto the application opening of the application tip. The application tip has a gripping means.