Methods and systems are provided for mixing and heat exchange of fluids. In one example, a fluid mixing and heat exchange device includes a hot water tank, a mixing chamber spaced away from the hot water tank and fluidly coupled to a first liquid reservoir, a first chilling module fluidly coupled to the mixing chamber, a coolant tank fluidly coupled to the first chilling module, a radiator fluidly coupled to the coolant tank, and a dispensing manifold fluidly coupled to the mixing chamber and adapted to dispense a mixed and chilled fluid mixture to a plurality of fluid vessels.

A filling device with a filling failure is identified less costly, and the filling amount by the filling device is adjusted quickly. The filling/sealing device includes a filler including a filling turret having a plurality of holding parts and a filling device provided for each of the holding parts to fill a container with a liquid content, forwarding turrets that hold and turret-convey a container transported from the filling turret, a sealing device that seals the container transported from the forwarding turrets with a lid, an inspection device provided in the path, in which the container is held and turret-conveyed, to inspect a filling amount in the container, and a controller that identifies a filling device with a filling failure on the basis of an inspection result from the inspection device and controls the filling amount by the filling device.

A filling device with a filling failure is identified less costly, and the filling amount by the filling device is adjusted quickly. The filling/sealing device includes a filler including a filling turret having a plurality of holding parts and a filling device provided for each of the holding parts to fill a container with a liquid content, forwarding turrets that hold and turret-convey a container transported from the filling turret, a sealing device that seals the container transported from the forwarding turrets with a lid, an inspection device provided in the path, in which the container is held and turret-conveyed, to inspect a filling amount in the container, and a controller that identifies a filling device with a filling failure on the basis of an inspection result from the inspection device and controls the filling amount by the filling device.

A liquid dispensing and vending apparatus comprises filling module(s), user container holder(s), positioning mechanism(s) and controller module(s). The filling module(s) comprise: machine container(s) configured to hold liquid(s), nozzle(s) configured to dispense liquid(s) to user container(s), and measuring pump module(s) configured to pump a measured amount of liquid(s) from machine container(s) to nozzle(s). The user container holder(s) are configured to hold user container(s). Positioning mechanism(s) align user container holder(s) with filing module(s). Controller module(s) execute production instructions causing liquid formulations to be dispensed into user container(s).

A liquid dispensing and vending apparatus comprises filling module(s), user container holder(s), positioning mechanism(s) and controller module(s). The filling module(s) comprise: machine container(s) configured to hold liquid(s), nozzle(s) configured to dispense liquid(s) to user container(s), and measuring pump module(s) configured to pump a measured amount of liquid(s) from machine container(s) to nozzle(s). The user container holder(s) are configured to hold user container(s). Positioning mechanism(s) align user container holder(s) with filing module(s). Controller module(s) execute production instructions causing liquid formulations to be dispensed into user container(s).

A system that fills multiple containers includes a filter with an inlet port and multiple outlet ports. The outlet ports are pre-attached to containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines is connected to a respective container interior. All of the respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. The system can produce batches of multiple sterile containers with sterile medicament in the containers.

A system that fills multiple containers includes a filter with an inlet port and multiple outlet ports. The outlet ports are pre-attached to containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines is connected to a respective container interior. All of the respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. The system can produce batches of multiple sterile containers with sterile medicament in the containers.

An apparatus for delivering a product into a container can include a filling unit, a drive unit configured to move the container with respect to the filling unit between a first position and a second position, and a controller. The filling unit can include a pump and a filling nozzle. The controller can: control delivery of the product through the filling nozzle; control the drive unit; register an operational end position of the drive unit corresponding to said second position; assign the registered operational position as a new initial position for the drive unit; calculate a new drive unit motion profile for controlling movement of the container from said second position to said first position based on said new initial position of the drive unit; and initiate delivery of the product through the filling nozzle into the container before the drive unit reaches said operational end position.

An apparatus for delivering a product into a container can include a filling unit, a drive unit configured to move the container with respect to the filling unit between a first position and a second position, and a controller. The filling unit can include a pump and a filling nozzle. The controller can: control delivery of the product through the filling nozzle; control the drive unit; register an operational end position of the drive unit corresponding to said second position; assign the registered operational position as a new initial position for the drive unit; calculate a new drive unit motion profile for controlling movement of the container from said second position to said first position based on said new initial position of the drive unit; and initiate delivery of the product through the filling nozzle into the container before the drive unit reaches said operational end position.

A method produces a filled and closed container by the blow-moulding, filling and closing method. An initially open container part (52) is held in a mould (46) and has been vacuum-moulded and/or blow-moulded by a blow pin and is filled successively with media (74, 76) of different types, in particular viscosity, by metering units (12, 14) via its free, upwardly directed container-part opening (54). The filled-in media (74, 76) are separated from one another in the container part (52), and subsequently, by closing of the top mould halves (56, 58) of the mould (46). A container top part (60) is moulded, and the container part (52) is closed, forming the container.