A filling and sealing system is provided for efficiently filling a series of individual vials with therapeutic liquids. In particular embodiments, the system includes a filling zone or station, a sealing zone or station, an unloading zone or station, and electronic controls.

A container and method for filling same. The container includes a penetrable and resealable portion that is resealable, and a container body having a sealed empty chamber in fluid communication with the penetrable and resealable portion for receiving therein a substance. The container also includes a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. Each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion. The method of filling the container includes penetrating the penetrable and resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member while engaging the base of the body to substantially prevent upward movement of the body, and applying energy to the penetrable and resealable portion to form a gas-tight seal.

The invention relates to a container, in particular a plastic ampoule which is produced using a blow moulding process, and which is filled and closed in the production mould, said container having a sleeve-type neck part (4) connected to a container body (2) as an axial extension, said neck part forming a seat (6) for a pre-formed insert (8) extending along the axis (12) of the neck part (4), and said neck part being formed in the production mould, on a peripheral region (14) of the insert (8), characterised in that at least one sealing element (42; 68) is provided on the insert (8), said sealing element forming a seal in a sealing region surrounding the axis (12), in combination with a contact surface (38) formed on the seat (6) of the neck part (4).

Disclosed is a method of sealing a container with a liquid, the container including a body with an opening at at least one end and including at least one sealing plug, designed to seal the opening after filling, the filling defining a free surface S for filling, the filling having allowed a head space to remain in the container. The method includes: introduction of at least one rod parallel to an inside wall of the body of the container; mechanical insertion of the plug in the body, along the at least one insertion rod, generating at least one channel C, the air of the head space being evacuated between the plug and the rod; and withdrawal of the at least one rod while leaving the plug in place at the level of insertion of the preceding step. Also disclosed are the associated device and the industrial production line.

A feeding unit which is configured to feed articles from a pick-up station to a delivery station. The feeding unit comprises: a gripping head provided with at least one gripping means and attached to a shaft. The shaft is configured to translate along the rotation axis between a lowered position, in which the articles are picked up and released by the gripping head, and a raised position, in which the gripping head rotates between the pick-up station and the delivery station. The feeding unit comprises two actuators which are coaxial to the shaft and which are configured to respectively translate the shaft between the lowered position and the raised position along the rotation axis and to rotate the shaft around the rotation axis between the pick-up station and the delivery station.

A method of packaging a two component composition into a dual vial (100), wherein the dual vial (100) comprises a single continuous piece of material arranged to provide both a first vial (110) and a second vial (120), the method comprising providing a second component of the composition into a volume, of the second vial (120), surrounding the first vial (110), providing a first component of the composition into a first vial (110), wherein the first vial (110) is nested within a second vial (120), and closing the first vial (110) and the second vial (120).

A method is provided for preparing spray dried powder containing vancomycin hydrochloride. The method comprises providing a vancomycin hydrochloride solution with a chromatographic purity of at least 95%, adding an excipient to the vancomycin hydrochloride solution to form a mixture solution of the vancomycin hydrochloride solution and the excipient, concentrating the mixed solution of the vancomycin hydrochloride solution and the excipient to form a 20% to 30% vancomycin concentrate, filtering the vancomycin concentrate to form a final filtrate, and spray drying the final filtrate to form a spray dried vancomycin hydrochloride powder with EP impurity B level of not more than 1.5%.

A device that has a device body defining an opening at one end thereof, a storage chamber within the device body for storing multiple doses of a substance therein, and a sliding stopper, sealing engageable with the device body, through which the chamber is filled. The stopper has a body and a flexible portion, which may be in the form of a plurality of flexible members, extending therefrom. The flexible portion or members are movable between first and second positions. In the first position, during filling, the portion or members are substantially laterally extending from the stopper body and engaging the opening of the device body. Accordingly, the axial position of the stopper with respect to the device body is secured during filling of the chamber therethrough. In the second position, after filling, the portion or members are substantially axially-extending from the stopper body and disengaged from the rim or opening of the device body. Accordingly, the stopper is axially slideable through the body.

Apparatus for filling devices that are penetrable for filling the devices with a substance, and resealable for sealing the resulting hole. A device support supports at least one such device in a substantially fixed position relative to the support during filling and/or resealing. A manifold drivingly mounted over the device support can include (1) a cartridge including a filling needle for penetrating a resealable stopper and introducing a substance therethrough into the device, a mount for mounting the cartridge on the manifold, and a removable cover releasably coupled to the mount for covering the filling needle during transportation, installation and/or removal of the cartridge from the manifold. The manifold can include a thermal source for heating a penetrated region of the stopper and, sealing the hole.

Device and method for needle penetrating and filling a chamber with a predetermined substance, and hermetically resealing a resulting needle hole in the device by applying radiation thereto. The needle penetrable and resealable portion defines a predetermined wall thickness in an axial direction thereof, and may include a thermoplastic that substantially prevents the formation of particles released into the chamber from the needle penetrable and resealable portion during penetration by and withdrawal of the needle. Such thermoplastic may include a predetermined amount of pigment that allows the thermoplastic to substantially absorb laser radiation at a predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness thereof, and hermetically seal a needle aperture formed in the needle penetration region thereof in a predetermined time period.