A closure for a pharmaceutical vial. The closure comprises an aluminum foil with an inductively meltable adhesive, an elastic seal, and a cap. The cap has an opening through which a perforating cannula can be inserted.

The invention relates to a device for vacuum stoppering a medical container. The device includes a main body defining an internal volume that has a variable pressure chamber configured to be connected to a vacuum pump. A stopper holder system is arranged in communication with the variable pressure chamber and is configured to receive and hold a stopper aligned with the direction of travel of a piston rod. A piston rod is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position wherein the piston rod pushes the stopper into the medical container. A container holder system provided in the main body, is arranged distally relative to the stopper holder system and in communication with the variable pressure chamber.

A manufacturing method of two-chamber type combined container-syringe including: a vacuum plugging process (S2) of eliminating air bubbles from the dissolving solution of the dissolving solution-filled cartridge and sealing the dissolving solution with a middle stopper after the dissolving solution filling process (S1); a vacuum plugging process (S2) has a first cooling processing (S21) of cooling the inside of a vacuum plugging equipment in which a dissolving solution-filled cartridge is disposed to a cooling temperature that does not freeze the dissolving solution, a first decompression processing (S23) of decreasing a pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing (S21), and a middle stopper pushing processing (S24) of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing (S23). The dissolving solution can be easily filled in a bubble-free state in the two-chamber type combined container-syringe.

A method for producing prick test single use sterile vials for use in a prick test is provided. The method comprises providing at least one allergen source including therewithin allergen extract, providing a plurality of single dose vials, connecting a tube to the at least one allergen source, connecting a metering device to the tube, drawing by the tube an amount of the allergen extract from one of the at least one allergen source, receiving the amount of allergen extract at the metering device, and dispensing by the metering device a volume of allergen extract into one of the plurality of single dose vials.

A production method for a closed glass container containing at least one solid body is disclosed. The method includes providing a tube tapering toward one end, the inner diameter of which is smaller at a tapered end than an inner diameter at an opposite first end. The tube is connected at the tapered end to a first end of a straight bar tube. The tapered tube is charged with at least one solid body.

A pharmaceutical mobile machine to produce a sterile dosage pharmaceutical form from non-sterile or sterile ingredients amenable for human dosing and administration, The pharmaceutical machine includes an ingredient combiner module including a mixer to mix active and inactive pharmaceutical ingredients and a transfer conduit to transfer the mixed ingredients from the ingredient combiner module. A final product module is operatively connected to the transfer conduit to receive the mixed ingredients from the ingredient combiner module. The final product module includes filling equipment to fill one or more containers to produce the sterile dosage pharmaceutical form. An environment module includes an air purifying system having an outlet operatively connected to the final product module, wherein the air purifying system provides purified air to the final product module through the outlet.

Apparatus for performing operations on semi-finished devices for producing disposable cartridges for electronic cigarettes includes: a guide having a branch extending along a forming direction, and having a longitudinal plane; carriages movable along the guide, each guide includes a retaining element to retain a semi-finished device during operations thereon; a drive system for advancing the carriages along the guide; and operating stations spaced from each other along the forming direction, each having an operating arrangement for performing operations on the semi-finished devices carried by the retaining elements applying stresses on the semi-finished devices; wherein: the retaining element is arranged laterally relative to the longitudinal plane, the apparatus includes a stationary support located at the operating stations, and each of the carriages includes a contrast element cooperating with the stationary support and arranged to transfer stresses applied by the operating arrangement on the semi-finished devices to the stationary support.

The present invention relates to a device for vacuum and vent tube stoppering a medical container. The device includes a main body defining an internal volume that has a first variable pressure chamber configured to be connected to a vacuum pump, the main body being configured to receive the proximal end of a medical container so that said medical container is in communication with the first variable pressure chamber. A vent device including a vent tube is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position. A piston rod is moveable inside the internal volume of the vent tube along the longitudinal axis between a proximal rest position and a distal operative position. A container holder system is provided in the main body, in communication with the first variable pressure chamber.

A non-addictive analgesic sustained-release drug delivery system, comprising: (1) a narcotic analgesic drug having a concentration of 1 mg/ml-160 mg/ml, the drug being selected from a group consisting of: a local analgesic drug, and the combination of the local analgesic drug and a nonsteroidal analgesic drug and/or an opioid analgesic drug; (2) a drug menstruum in a proportion of 1%-75% (v/v), the menstruum being selected from a group consisting of benzyl alcohol, ethanol, benzyl benzoate, ethyl lactate, and tetrahydrofurfuryl polyethylene glycol ether; and (3) a drug sustained-release formulation having a proportion of 25%-99% (v/v), the sustained-release formulation being selected from a group consisting of natural vegetable oil, synthetic lipid, artificially improved half-natural lipid and derivative thereof. Also disclosed are a preparation process and use of the sustained-release drug delivery system.

A device for sealing sample tubes comprises a tool assembly configured to interface with a rack holding a plurality of sample storage tubes, the tool assembly holding a plurality of punches and a die plate including a plurality of cutting holes, with each of the plurality of cutting holes accepting one of the plurality of punches. The tool assembly receives a foil sheet between the punches and the die plate. The device includes an actuator enabling linear movement of the tool assembly. Linear movement of the tool assembly towards the rack engages the die plate against the rack and punches the punches through the cutting holes of the die plate to punch a plurality of sealing sections from the foil sheet and to press and seal each of the sealing sections against a top end of each of the plurality of sample storage tubes in the rack.