Sterilizing packaging units including packing a sterilization container by receiving a rigid body having a lower surface, an upper rim, and side walls between the lower surface and the upper rim, wherein the upper rim defines an opening to an interior space of the body, arranging one or more packaging units in the interior space of the body, covering and sealing the opening of the body with a lid, and engaging a valve body in fluid communication with the interior space of the body to move the valve body to an open position; exposing the interior space of the body and the packaging units to a sterilant until the packaging units are sterilized; subjecting the interior space of the body to a negative pressure differential; and engaging the valve body to move the valve body to a closed position that seals the interior space of the body.

Systems and methods of aseptic processing of product can include a hopper for introduction of the product into the system and one or more components through which the product flows as it is processed through the system, an enclosure surrounding one more of the components, a gassing assembly comprising a plurality of gassing elements for maintaining a substantially constant flow of inert gas over the product as it travels through the components of the system, and filtered gas recirculation system that recirculates filtered air or gas through the enclosure. Such systems can be particularly advantageous for use in the cannabis industry.

A plant (1) for filling and closing cans (2) under hygienic conditions which comprises a hygienic compartment (3), a lid applying device (7) and an inlet (30) for a filling material. The lid applying device (7) is arranged in the hygienic compartment (3) and the inlet (30) is formed on the hygienic compartment (3). When used as intended, one or more cans (2) can be assigned to the hygienic compartment (3) and the hygienic compartment (3) can be moved together with the can(s) (2) in the system (1).

A containment system and assembly for the automated production of pharmaceutical or biotechnical articles is provided. The containment system has a housing within which there is an inner chamber having at least one through opening. One or more robots are installed in the chamber, which have a manipulating element on the pivotable arms, which can move within a pivot range. One or more process units are installed in the chamber for the production of the articles. The chamber includes a process space for the production of the articles and a tub-shaped base space for anchoring the feet of the robots to the side surfaces inside the base space. The manipulating element functions as a gripping and transportation device for inspecting the articles or article parts and/or for the production of the articles.

A filling device for dosed filling of a product from a product storage container into product dose receiving containers provided in a disposable isolator so to be protected against contamination. The device includes means for holding the product storage container together with the contents outside of the disposable isolator. The device includes a controllable product removal device for a dosed removal of the product from the product storage container. The device includes a product dispensing device for the dosed dispensing of the product to the product dose receiving containers. The device includes a line assembly interconnecting the product storage container and the product dispensing device to conduct the product to the product dispensing device. The device includes at least one ultrasonic flowmeter outside of the disposable isolator fixed to the outside of the line assembly to detect the flow rate. The device includes a controller for measuring the product dose.

A method of sterilizing a prefilled syringe comprises assembling a syringe assembly and performing at least one ethylene oxide (EtO) sterilization procedure cycle. The assembling step includes inserting a tip cap at a first end of a plunger, filling a non-glass barrel with sterilization sensitive material at a second end of the barrel, and inserting the plunger into the barrel at a second end to seal the sterilization sensitive material within the barrel. The EtO sterilization procedure cycle comprises undergoing a preprocessing stage, a wash and conditioning stage, an EtO sterilization stage and a wash and post exposure stage. Upon completing the EtO sterilization procedure cycle, a resultant pH of the sterilization-sensitive material does not exceed an acceptable pH range as defined by the United States Pharmacopeia. The disclosure also discusses inserting an assembled prefilled syringe into a procedure tray prior to performing the EtO sterilization procedure cycle.

The present invention relates to a method and system for aseptically filling of flexible packages containing dry cloth. Such a method may include a first stage that is performed in a non-sterile environment. The first stage may include cutting a first substantially dry cloth to a predetermined size; inserting the first cloth into a flexible package; sealing a first end of the flexible package; and sterilizing the flexible package. The method may also include a second stage performed in a sterile environment. The second stage may include filling the flexible package with a medical solution such that the substantially dry cloth absorbs at least a portion of the medical solution; and sealing the open end of the flexible package.

Systems and methods permit gloveless filling containers with a product. A filling arm is disposed within the chamber. An optical sensor is configured to locate and target openings of the containers within the chamber. Locations of the openings are used to guide the filling arm to fill the containers with a product.

A medical dispensing system with dispensing and pathway components, each of which of a plurality of dispensers and pathways, respectively. The dispensing and pathway components are controlled to minimize contamination between the items being dispensed. Both the dispensing and pathway components have arcs around which the dispensers and pathways are arranged.

Provided is a novel container sterilization method in which no liquid agent is used. A container sterilization method is a method of performing sterilization by supplying a sterilization component to a container that is continuously conveyed along a predetermined conveyance path, the container sterilization method including supplying a humid ozone gas to a sterilization area, the humid ozone gas being an ozone gas that has humidity, the sterilization area being partitioned by a sterilization chamber that contains the conveyance path. The humidity of the humid ozone gas to be supplied to the sterilization region is regulated, depending on a temperature of the containers to be conveyed to the sterilization region.