A system of managing the sterilisation of empty flexible pouches (1) provides applying sacrificial closures (200) to the empty pouches, loading the empty provisional closed pouches to be sterilised on a transport device (300) for the collective transportation, performing the sterilisation of the transport device (300) carrying the empty provisional closed pouches, and finally separating, in a sterile chamber, the sacrificial closures (200) from the pouches, filling and applying a tamper-proof cap (100).

According to embodiments of the present invention, a material transfer station provides a base frame equipped with a table member, a container tipper, an operator interface, and a connection to a power source. In operation, a destination container is positioned beneath the table member, and the container tipper holds a supply container. Solid matter may be conveyed from the supply container into the destination container through an opening in the table member. Modules may be attached to provide additional functionality, such as a receiving module, a containment module, a vibratory screener, a flexible film isolator, and a nitrogen purge system.

A transport and packaging container for a plurality of pharmaceutical containers and a method for transferring the pharmaceutical containers from the transport and packaging containers into a clean room are provided. By placing a side wall of the transport and packaging container in close proximity to or in contact with the side wall of the clean room and by opening the side wall of the transport and packaging container and a transfer port door of the clean room, the pharmaceutical containers can be transferred into the inside space of the clean room via the access opening.

A device to package a sterile bulk product, particularly, a dermocosmetic or galenic preparation, into a container. A sterile enclosure of the device includes a hopper containing the bulk product. The hopper includes in an axial direction, a cylindrical reservoir part and a pouring part connected to the cylindrical part. A transfer device transports the container under the hopper to fill the container in a filling zone. A blower provides ultra-filtered air from the ceiling to the floor of the enclosure, to produce a protective flow of air around the filling zone. The axis of the pouring part with an asymmetrical conical shape is not in line with the axis of the reservoir part such that the pouring opening is shifted towards the outer wall of the reservoir.

Methods and apparatus for the sanitization, detoxification, disinfection, high level disinfection, or sterilization of both the interior and exterior surfaces of at least one object.

Medical devices such as medical containers can be formed of glass and annealed which produces a clean device having a low bio-burden, or formed by plastic molding which produces a clean device. The clean devices are immediately transferred to a controlled environment such as a clean room or localized area to avoid the need to maintain cleanliness levels in an entire room. Syringe tip closures can be introduced into the housing assembly, where syringe barrels and tip closures are cleaned with filtered ionized air and the tip closures are coupled to the barrels. The syringe barrels can be filled with a substance and a closure member attached. While still in the housing assembly the syringe barrels can be formed into an array and placed in a clean outer container, which is then closed and sealed.

One embodiment of the present invention provides a method for processing plastic containers within an open aseptic converter chamber comprising a sanitized environment, a supply line, a sanitizer device, a perforator device, a sealing device, and a conveyer. During operation, the method includes: providing and filling a container with heated or heatable liquid including water; sealing the container with a seal or cap; cooling the container to create a first headspace pressure; enclosing the container within the chamber; creating an opening in the seal or cap within a sanitized environment of the perforator device; increasing the first headspace pressure to a second headspace pressure by introduction of a sanitized fluid; resealing the container within a sanitized environment of the sealing device; and, transporting or conveying the sealed container away from the chamber.

There is described a packaging apparatus for forming a plurality of sealed packages comprising a conveyor for advancing a web of packaging material along an advancement path, an isolation chamber, a tube forming device adapted to form a tube from the, in use, advancing web of packaging material, a sealing device adapted to longitudinally seal the tube, a filling device for continuously filling the tube formed by the tube forming device, a package forming unit adapted to form and seal the packages from the, in use, advancing tube formed by the tube forming device and filled by the filling device and a support platform supporting the isolation chamber from a first side of the support platform and carrying the package forming unit from a second side of the support platform opposite to the first side.

The invention relates generally to a sanitizing device that may comprise of an enclosure, a conveyor module, a plurality of sanitizing light sources, and possibly a sealing module. Objects that need to be sanitized may be transported or placed inside the enclosure and can be exposed to sanitizing lights from a plurality of sanitizing light sources. After the exposure to the sanitizing lights, the objects may convey out of the apparatus or go through a sealing module before exiting the enclosure. The conveyor module of the sanitizing device may be driven by torque created by an exterior conveyor belt or a motorized mechanism integrated within the apparatus.

A device (1) for closing a chamber of a container having an opening for accessing the chamber comprises a plunger, a plunger seat (11), a container carrier (13) and a spacer (12). The plunger seat (11) releasably holds the plunger in a predefined alignment. The container carrier (13) is arranged to be connected to the container in a predefined position and alignment in relation to the opening of the container. The spacer (12) is arranged to position and align the plunger seat (11) adjacent to and distant from the container carrier (13) such that the opening of the container is open when the container is connected to the container carrier (13).