The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.

The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.

A method of manufacturing a spouted pouch aseptically filled with contents includes a supplying process, a sterilizing process, a stopper opening process, a filling process, a tightly re-stopping process, and a capping process. The sterilizing process, the stopper opening process, the filling process, and the tightly re-stopping process are performed in an aseptic chamber.

A method of manufacturing a spouted pouch aseptically filled with contents includes a supplying process, a sterilizing process, a stopper opening process, a filling process, a tightly re-stopping process, and a capping process. The sterilizing process, the stopper opening process, the filling process, and the tightly re-stopping process are performed in an aseptic chamber.

Embodiments of the present disclosure are directed to a biological tissue packaging system, as well as a transport system, and, in some embodiments, comprises a first package, a secondary package, and a tertiary package. Each of the first, second, and tertiary packages is sterilized prior to packaging of a biological tissue therein. The first package comprises a pouch, and a first tray and a first lid configured for removable snap-fit attachment to one another so as to form a clamshell container. The secondary package is configured to contain the first package and interlock therewith. The tertiary package is configured to contain the secondary package and interlock therewith.

Embodiments of the present disclosure are directed to a biological tissue packaging system, as well as a transport system, and, in some embodiments, comprises a first package, a secondary package, and a tertiary package. Each of the first, second, and tertiary packages is sterilized prior to packaging of a biological tissue therein. The first package comprises a pouch, and a first tray and a first lid configured for removable snap-fit attachment to one another so as to form a clamshell container. The secondary package is configured to contain the first package and interlock therewith. The tertiary package is configured to contain the secondary package and interlock therewith.

A method for treating open cut edges of a packaging sleeve, blank or web material of a packaging material rolled up into a roll, in particular a composite cardboard/plastics material, by applying or introducing a disinfectant-containing treatment agent to or into the outer region of the cut edges. To provide a particularly resource-efficient composite packaging and a production method required for this purpose, it is proposed that at least some of the treatment agent is not applied directly to the cut edges, but that a load carrier is loaded, which load carrier absorbs the treatment agent so that an actively sterilising atmosphere which is created then acts on the open cut edges of the packaging sleeve, blank or web material and performs the desired sterilisation. The invention also relates to a packaging material, to a combipack produced therefrom and to a container for receiving the packaging material.

A method for treating open cut edges of a packaging sleeve, blank or web material of a packaging material rolled up into a roll, in particular a composite cardboard/plastics material, by applying or introducing a disinfectant-containing treatment agent to or into the outer region of the cut edges. To provide a particularly resource-efficient composite packaging and a production method required for this purpose, it is proposed that at least some of the treatment agent is not applied directly to the cut edges, but that a load carrier is loaded, which load carrier absorbs the treatment agent so that an actively sterilising atmosphere which is created then acts on the open cut edges of the packaging sleeve, blank or web material and performs the desired sterilisation. The invention also relates to a packaging material, to a combipack produced therefrom and to a container for receiving the packaging material.

A system of managing the sterilisation of empty flexible pouches (1) provides applying sacrificial closures (200) to the empty pouches, loading the empty provisional closed pouches to be sterilised on a transport device (300) for the collective transportation, performing the sterilisation of the transport device (300) carrying the empty provisional closed pouches, and finally separating, in a sterile chamber, the sacrificial closures (200) from the pouches, filling and applying a tamper-proof cap (100).

A system of managing the sterilisation of empty flexible pouches (1) provides applying sacrificial closures (200) to the empty pouches, loading the empty provisional closed pouches to be sterilised on a transport device (300) for the collective transportation, performing the sterilisation of the transport device (300) carrying the empty provisional closed pouches, and finally separating, in a sterile chamber, the sacrificial closures (200) from the pouches, filling and applying a tamper-proof cap (100).