A system for filling multiple sterile containers includes a filter with an inlet port and multiple outlet ports, the outlet ports being pre-attached to sterile containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines are connected to a respective container interior. The respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. A container that is connectable to an outlet port the system has a bladder, a first tube and a second tube connected to the bladder, and a sterilizing filter. The container, the first tube and the second tube, and the sterilizing filter are sterile before water is flowed through the sterilizing filter into the bladder.

A cap sterilizer (50) includes an infeed chamber (52), a sterilant atomizing chamber (53), and an air rinse chamber (54). At least the infeed chamber (52) and the air rinse chamber (54) are exhausted. Both an exhaust pressure (E2) in the infeed chamber (52) and an exhaust pressure (E4) in the air rinse chamber are higher than an exhaust pressure (E3) in the sterilant atomizing chamber (53), or the sterilant atomizing chamber (53) is not exhausted.

Provided is a novel container sterilization method in which no liquid agent is used. A container sterilization method is a method of performing sterilization by supplying a sterilization component to a container that is continuously conveyed along a predetermined conveyance path, the container sterilization method including supplying a humid ozone gas to a sterilization area, the humid ozone gas being an ozone gas that has humidity, the sterilization area being partitioned by a sterilization chamber that contains the conveyance path. The humidity of the humid ozone gas to be supplied to the sterilization region is regulated, depending on a temperature of the containers to be conveyed to the sterilization region.

Provided is a novel container sterilization method in which no liquid agent is used. A container sterilization method is a method of performing sterilization by supplying a sterilization component to a container that is continuously conveyed along a predetermined conveyance path, the container sterilization method including supplying a humid ozone gas to a sterilization area, the humid ozone gas being an ozone gas that has humidity, the sterilization area being partitioned by a sterilization chamber that contains the conveyance path. The humidity of the humid ozone gas to be supplied to the sterilization region is regulated, depending on a temperature of the containers to be conveyed to the sterilization region.

The present disclosure provides novel processes for providing sterile, pre-filled syringes or injection devices for pharmaceutical compositions, including protein and biopharmaceutical formulations. In some examples, secondary packaging is performed in an aseptic environment, which removes the need for any terminal sterilization method. In some examples, the aseptic packaging method results in a sterile injection device suitable for use in ophthalmic injections.

Disclosed is a container treatment apparatus and treatment method, in particular a container sterilisation apparatus, having a plurality of transport devices for transporting a container along a predetermined transport path, at least one of the transport devices having at least one holding device for holding at least one container during container treatment and/or transport along the transport path, the transport device having a rotatable carrier and a plurality of holding elements arranged on this carrier, wherein a holding element in a first sector, in which a container is received, having a height with respect to a perpendicular projection of the transport path which is different from that in a second sector in which a container is dispensed, and wherein a sector in which an at least partial compensation of the height difference of the holding elements takes place lies along a direction of rotation of the carrier after the second sector and before the first sector.

Provided is a novel container sterilization method in which no liquid agent is used. A container sterilization method is a method of performing sterilization by supplying a sterilization component to a container that is continuously conveyed along a predetermined conveyance path, the container sterilization method including supplying a humid ozone gas to a sterilization area, the humid ozone gas being an ozone gas that has humidity, the sterilization area being partitioned by a sterilization chamber that contains the conveyance path. It is preferable that the humid ozone gas to be supplied to the sterilization area have a higher temperature than the container to be conveyed to the sterilization area and the sterilization chamber have a higher temperature than the container to be conveyed to the sterilization area.

Provided is a novel container sterilization method in which no liquid agent is used. A container sterilization method is a method of performing sterilization by supplying a sterilization component to a container that is continuously conveyed along a predetermined conveyance path, the container sterilization method including supplying a humid ozone gas to a sterilization area, the humid ozone gas being an ozone gas that has humidity, the sterilization area being partitioned by a sterilization chamber that contains the conveyance path. It is preferable that the humid ozone gas to be supplied to the sterilization area have a higher temperature than the container to be conveyed to the sterilization area and the sterilization chamber have a higher temperature than the container to be conveyed to the sterilization area.

Methods and apparatus for sterilizing and filling vessels which are kept in a sterile environment while being filled are capped before filling and immediately thereafter are ready to be displaced into a potentially contaminating environment while retaining a predetermined SAL are disclosed. Such vessels can be syringes use for dispensing Avastin or conventional syringes. Also method and apparatus for making an eye drop bottle using a conventional medical syringe which can be used in kits made according to the present invention are disclosed. In addition, a method for modifying conventional eye drop bottles for use in kits made according to the instant invention is disclosed. Further, a method for linking single convenience kits to form increased numbers of vessels filled by the same single act, used to fill a single convenience kit, is also disclosed.

A method for treating open cut edges of a packaging sleeve, blank or web material of a packaging material rolled up into a roll, in particular a composite cardboard/plastics material, by applying or introducing a disinfectant-containing treatment agent to or into the outer region of the cut edges. To provide a particularly resource-efficient composite packaging and a production method required for this purpose, it is proposed that at least some of the treatment agent is not applied directly to the cut edges, but that a load carrier is loaded, which load carrier absorbs the treatment agent so that an actively sterilising atmosphere which is created then acts on the open cut edges of the packaging sleeve, blank or web material and performs the desired sterilisation. The invention also relates to a packaging material, to a combipack produced therefrom and to a container for receiving the packaging material.