A container having a cylindrical pouring nozzle with an external thread and with a stop; a cap with an internal thread which can be screwed onto the external thread of the pouring nozzle as far as an end position in which the cap bears in the direction of rotation on the stop of the pouring nozzle; and a seal made of a material which is softer than a material of the cap and a material of the pouring nozzle. The seal is fixedly connected to the cap and has a first sealing element which, with the cap screwed on, is arranged in a radial direction between the cap and pouring nozzle and bears on a lateral surface portion of the pouring nozzle.

A container having a cylindrical pouring nozzle with an external thread and with a stop; a cap with an internal thread which can be screwed onto the external thread of the pouring nozzle as far as an end position in which the cap bears in the direction of rotation on the stop of the pouring nozzle; and a seal made of a material which is softer than a material of the cap and a material of the pouring nozzle. The seal is fixedly connected to the cap and has a first sealing element which, with the cap screwed on, is arranged in a radial direction between the cap and pouring nozzle and bears on a lateral surface portion of the pouring nozzle.

A cap for an applicator includes an inlet, a base having a connection portion embodied for connecting the cap to the applicator or a container formed therein, a head that receives an application part of the applicator within the head, and a projection formed at a top part of the cap. The top part formed at an opposite end to the inlet, and the projection cooperating with an outlet of the applicator. The head includes a cylindrical or conical inner or outer shape and the connection portion has a round inner or outer shape, that is an oval, round or square shape.

A cap for an applicator includes an inlet, a base having a connection portion embodied for connecting the cap to the applicator or a container formed therein, a head that receives an application part of the applicator within the head, and a projection formed at a top part of the cap. The top part formed at an opposite end to the inlet, and the projection cooperating with an outlet of the applicator. The head includes a cylindrical or conical inner or outer shape and the connection portion has a round inner or outer shape, that is an oval, round or square shape.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

A closure system is disclosed for closing an opening of a container. The system includes a stopper member made of an elastic material, a plug portion configured to tightly fit into the container opening and a cover portion configured to abut a boundary surface adjacent to the container opening. A cage member of the system is made of a shape-retentive material, and includes a stopper contacting section, a clipping structure and an intermediate section therebetween. The clipping structure is configured to clip in a corresponding structure of the container. The cage member is configured such that the stopper contacting section applies a pressure to the stopper member cover portion to push the stopper member cover portion onto the boundary surface of the container opening, when the stopper member plug portion is fitted into the container opening and the cage member clipping structure clips in the corresponding structure of the container.

A closure system is disclosed for closing an opening of a container. The system includes a stopper member made of an elastic material, a plug portion configured to tightly fit into the container opening and a cover portion configured to abut a boundary surface adjacent to the container opening. A cage member of the system is made of a shape-retentive material, and includes a stopper contacting section, a clipping structure and an intermediate section therebetween. The clipping structure is configured to clip in a corresponding structure of the container. The cage member is configured such that the stopper contacting section applies a pressure to the stopper member cover portion to push the stopper member cover portion onto the boundary surface of the container opening, when the stopper member plug portion is fitted into the container opening and the cage member clipping structure clips in the corresponding structure of the container.

The invention relates to a capsule (1) for a flanged cork stopper, the capsule (1) having a body (2) comprising a top (3) and a cavity (4) inside which at least two anti-rotation splines (5) are arranged, and the capsule further comprising an axial retention chamber (6) disposed within said cavity (4), wherein retention chamber (6) is shaped to receive and axially retain a flange of a flanged cork stopper. The invention also relates to a capsulated stopper comprising a flanged stopper, the flange of which is attached to the capsule (1) of the invention. The invention further relates to the production process of said capsulated stopper.

A vial closure assembly (10) for sealing a container (12) includes a ring (28), a cap (32), a shell (70), and an optional cover (30). The ring has a first top wall (34) defining a first central through-opening (29) and a skirt (36) extending downwardly from the first top wall that includes a plurality of locking tabs. The cover includes a second top wall (54) defining a second central through-opening (58), a sidewall (56) extending downwardly from the second top wall, and an interior cavity (57) defined by the second top wall and the sidewall. The cap includes a plurality of tabs (66) configured to engage the first or second top wall. The shell includes a barrel-shaped body (71) having an inwardly radially extending upper (72) and lower lip (74), such that the shell is configured to captivate the cover or ring. The upper lip includes at least one rail (76) for sliding contact with a top surface of either the first or second top wall.