An apparatus includes a drinking container and a lid. The lid encircles a portion of the drinking container, and includes a body and a rim. The body is formed of an elastomeric material and defines a hollow pocket with an open end and an aperture or scored region. The rim is formed of the elastomeric material and defines a ring running about the open end. Lids in accordance with aspects of the invention are capable of capturing and suspending straws, and preventing spills.

An apparatus includes a drinking container and a lid. The lid encircles a portion of the drinking container, and includes a body and a rim. The body is formed of an elastomeric material and defines a hollow pocket with an open end and an aperture or scored region. The rim is formed of the elastomeric material and defines a ring running about the open end. Lids in accordance with aspects of the invention are capable of capturing and suspending straws, and preventing spills.

A security cover system and apparatus for beverage cans and other containers. The system includes a security cap that is installed upon the top of an unopened container for containing an adult beverage or the like. The cap is adapted for secure installation upon the top of a container having a top with a circumferential rim, such as an aluminum beverage can. The cap has catches engagable with the rim of the container. The system includes an opener tool with a specially shaped key portion thereon. The opener engages with a complementary slot in the cap to permit an authorized person, using the opener tool, to remove the cap from the container.

The metering device includes a metering container which can be fitted with screwing action on a standard bottle neck. The metering container has a funnel-shaped base, which is adjoined by a cylindrical lateral wall having, at the upper end, a cross-sectionally u-shaped collar, to which a cover surface can be applied in a form-fitting manner. At the top of the metering device is a pressure-exerting head with an encircling, detachable periphery. A puncturing mechanism having a two-part pressure-exerting pin can be actuated by the pressure-exerting head. The puncturing mechanism is fixed to the cover surface, prior to initial use, and is separated out of the cover surface by a cylindrical casing wall on the pressure-exerting head. The second part of the puncturing mechanism has a punching sleeve, which severs membranes which close the metering container, whereupon the contents of the metering container can be supplied into the bottle.

Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-β1) are provided, particularly recognizing human and mouse TGF-β1 and not recognizing or binding TGF-β2 or TGF-β3. Particular antibodies are provided which specifically recognize and neutralize TGF-β1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-β1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-β1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.

A re-closeable cap is outfitted upon an upper portion of a beverage can or a series of beverage cans in a multi-pack arrangement for providing a protective barrier atop opened beverage cans. The re-closeable caps include a unibody material construction particularly configured to comprise a cap rim and a cap plate centrally located relative to the cap rim. The cap rim attaches the re-closeable cap to a can rim. The cap plate includes a static portion and at least one dynamic portion all formed from the unibody material construction with complex upper surface landscape and cut lines. The dynamic portions are pivotal relative to the static structure for providing a can-opening access aperture for enabling a user to consume can contents and closing the can-opening access aperture for enabling the user to cover the can opening during contents consumption.

A bung plug closure (30) for fastening a plug depression formed in a bung plug (31), said plug depression comprising a receiving area for receiving a resilient engagement body realized on the seal cap (11), and said bung plug (31) comprising tool engagement projections (33), which are arranged on an inner wall of the plug depression and which are distanced to each other via gaps (34) and which delimit the receiving space using inner surfaces (37), counter-locking elements (32) being provided in the plug depression, said counter-locking elements (32) being arranged in the area of the gaps (34) above an annular frame (35, 61), which is formed outside of the gaps (34) via lower sections (36) of the inner surfaces (37).

A bung plug closure (30) for fastening a plug depression formed in a bung plug (31), said plug depression comprising a receiving area for receiving a resilient engagement body realized on the seal cap (11), and said bung plug (31) comprising tool engagement projections (33), which are arranged on an inner wall of the plug depression and which are distanced to each other via gaps (34) and which delimit the receiving space using inner surfaces (37), counter-locking elements (32) being provided in the plug depression, said counter-locking elements (32) being arranged in the area of the gaps (34) above an annular frame (35, 61), which is formed outside of the gaps (34) via lower sections (36) of the inner surfaces (37).

A packaging assembly for holding contents is provided. The packaging assembly includes a self-supporting liner having a wall that encloses sides and bottom of an interior of the liner and defines an open top end of the liner, and a rim that projects outwardly from the wall proximal to the open top end. The packaging assembly also includes a lidding assembly including a cover region and a destructible seal region that seals the cover region to the liner extending over and closing the liner open top. The destructible cover region is weaker than the liner and the cover region so that detachment of the cover region from the liner causes the destructible seal region to fail. The lidding assembly includes a first lidding material having a center portion and an outer portion that surrounds the center portion.

A packaging assembly for holding contents is provided. The packaging assembly includes a self-supporting liner having a wall that encloses sides and bottom of an interior of the liner and defines an open top end of the liner, and a rim that projects outwardly from the wall proximal to the open top end. The packaging assembly also includes a lidding assembly including a cover region and a destructible seal region that seals the cover region to the liner extending over and closing the liner open top. The destructible cover region is weaker than the liner and the cover region so that detachment of the cover region from the liner causes the destructible seal region to fail. The lidding assembly includes a first lidding material having a center portion and an outer portion that surrounds the center portion.