A tamper evident closure and spout are provided. The closure includes an outer wall and a central wall supported from the outer wall. The closure defines a passage extending between an upper edge and a lower edge of the closure and located between an inner surface of the outer wall and an outer surface of the central wall. The closure includes a tamper-indicating band extending from the central wall. The spout includes a wall portion and a central channel extending through the wall portion between an inlet opening and an outlet opening. The spout includes a structure located below the inlet opening the first and second exterior surfaces are both angled toward the central axis of the spout.

A time programmable container that includes a base for containing the object, a lid, a base, and a spacer which is positioned intermediate the lid and the base. The spacer is positionable in a select one of a plurality of positions on the base. The spacer and the base contain time indicia such that each of the plurality of positions that the spacer can be placed upon the base corresponds to a different of time indication. The base includes members to secure the spacer in the select one position. The lid includes a cavity on the bottom surface of a lip which mates with a tab on the spacer, such that when the spacer is placed upon the base and the lid is threaded onto the base, the tab secures prevents the removal of the lid from the base without first removing the tab from the cavity.

A container assembly including a pouch, spout and closure is provided. The closure includes a tamper-evident band having two or more wall sections. Adjacent wall sections of the tamper band may be connected to one another with frangible connectors configured to break upon twist-off of the closure from the spout. The closure also includes one or more support walls supported between an outer wall and central wall of the closure. The closure further includes one or more hinges attaching the ends of the wall sections of the tamper band to the lower ends of the support walls. The hinges are configured to increase the resistance required to break or otherwise distort the frangible connections of the tamper-evident band, so as to prevent or lower the risk of accidental or inadvertent breakage of the tamper-evident band prior to twist-off of the closure from the spout.

A single use filtering device comprises a filter body formed at least in part of a filter medium configured to hold a sample during filtration and a fastening element configured for releasably mounting the filtering device to a holder. The fastening element being adapted to undergo an irreversible structural alteration during the mounting or removal of the filtering device from the holder to prevent remounting of the filtering device to the holder.

A tamper evident closure and spout are provided. The closure includes an outer wall and a central wall supported from the outer wall. The closure defines a passage extending between an upper edge and a lower edge of the closure and located between an inner surface of the outer wall and an outer surface of the central wall. The closure includes a tamper-indicating band extending from the central wall. The spout includes a wall portion and a central channel extending through the wall portion between an inlet opening and an outlet opening. The spout includes a structure located below the inlet opening the first and second exterior surfaces are both angled toward the central axis of the spout.

Containers with closures are disclosed. A closure may include at least a polymer orifice reducer configured to be permanently secured to a rim of an opening of a container and a flexible tamper evident seal disposed on the topside of the orifice reducer. The flexible tamper evident seal, optionally foil, covers one or more openings in the orifice reducer. Processes for permanently securing a closure to a container, optionally by forming a heat seal between the orifice reducer and container rim, are also disclosed.

A tamper evident closure and spout are provided. The closure includes an outer wall and a central wall supported from the outer wall. The closure defines a passage extending between an upper edge and a lower edge of the closure and located between an inner surface of the outer wall and an outer surface of the central wall. The closure includes a tamper-indicating band extending from the central wall. The spout includes a wall portion and a central channel extending through the wall portion between an inlet opening and an outlet opening. The spout includes a structure located below the inlet opening the first and second exterior surfaces are both angled toward the central axis of the spout.

A closure (40) is provided for use in restricting access to a substance that may be stored within a container (44) having at least one laterally extending flange (76) located laterally outwardly of an opening (46) of the container (44). The closure (40) has a body (54) having a deck (58) including at least one orifice (60). The body (54) has an internal wall (62) depending from the deck (58) with means for attaching the closure (40) to the container (44) and the body (54) includes at least one torque rib (74) extending therefrom for confronting at least one laterally extending flange (76) of the container (44) to inhibit relative rotation between the body (54) and the container (44). The at least one torque rib (74) is non-planar.