A locking cover for a container having a neck comprising: a cage made from plastic; a body made from plastic, which is fastened around the cage, the body comprising a central orifice; a cap configured to close the central orifice, the cap comprising a flat head to cover the orifice and fastening lugs caught between the cage and the body. Each fastening lug has a breakable zone, and the cap is made from a plastic material, different from the plastic material of the cage and from the plastic material of the body, the plastic material of the cap being chosen to have a resistance to rupture reduced by a dose of gamma irradiation for sterilizing the locking cover.

A tamper-evident container (1) including: a store (2) for housing at least one product, a closure system (7) placed at a passage opening (5) of the store (2) and configured for obstructing said passage opening to define a closed condition of the container (1). The store (2) has at least one glued portion at which a layer (40) made of heat-sensitive material is arranged, configured for irreversibly varying, following a heating of said layer (40), an optical and/or physical property of the same layer to provide evidence of an attempted tampering of the container (1).

Many embodiments described herein prevent an aged spirit from degrading due to the oxygen trapped in the headspace without the use of a pump. The aged spirit preservation system may have a cork with an open top, an open bottom, and a channel extending from the open top to the open bottom. The cork may be sized couple to an internal portion of a bottle. The system may even include a sealing device coupled to an outer portion of the cork between the open top and the open bottom. Additionally, the system may include a replaceable cartridge containing an adsorbent media, iron, a salt, and a color-changing indicator. Oxygen from the bottle may be allowed to enter the cartridge and react with the iron via a non-reversible reaction, thereby preventing the degradation of the spirit.

A package for shipping a product ordered via the Internet. The package comprising a container body, an inner label, a closure, an outer label removably attached to and covering all or part of the inner label, and a shipping label adhered to the outer label.

A tamper-evident closure for a container includes a straw having an outer edge with an outwardly extending projection. The closure includes a cap with a rib. A tamper-evident tab extends from the rib. The tab has an inwardly extending lug configured to engage with the outwardly extending projection of the straw as the cap rotates relative to the straw when the cap and the straw are secured together. The tab has a has a foldable portion configured to fold the lug inwardly to provide a visual indication when the cap is an unsealed configuration.

A tamper-evident seal for use with a container includes a body that is sealably coupled to a boundary defining an opening providing access into the container. The seal includes a gripping portion having a fixed end and a free end, the fixed end extending from the body, wherein the free end is sized and shaped to be gripped by a user to enable the user to forcibly disconnect at least a portion of the body from the container. The seal further includes an indicator including an indicator body, a neck portion of the indicator is removably coupled to the gripping portion, such that when the body is at least partially removed from the boundary, at least a portion of the indicator body remains connected to the body, as the gripping portion is disconnected from the indicator when the neck portion is uncoupled from the gripping portion.

A method for preventing tampering with a package includes: affixing a plurality of labels to a physical package, each label including a machine-readable code, the machine-readable code being encoded with a unique value that is unique across the machine-readable code included in each of the plurality of labels; reading, by a computing device, the machine-readable code included in each label of the plurality of affixed labels to obtain the encoded unique value; storing, in the computing device, a cryptographic key pair comprised of a public key and a private key; generating, by the computing device, a digital signature using the private key; and electronically transmitting, by the computing device, a data message to a node in a blockchain network, wherein the data message includes at least the generated digital signature, the public key, and the unique value read for each label of the plurality of labels.

The present invention is directed to tamper-evident mesh material, methods of manufacture therefor, and tamper-evident bags manufactured therefrom. The tamper-evident mesh material of the present invention may be used, for example, in the manufacture of a variety of tamper-evident security bags for use in applications where it is desirable to detect any traces or evidence of tampering with or of unauthorized access to the contents of the bag.

A tamper-evident container comprising a vessel and a barrier that together enclose an interior space. The barrier has a marking chamber at least partially filled with a marking substance, such that when a product is inserted into the tamper-evident container through the barrier and passes through the marking chamber, the marking substance is applied to the product's surface. The presence of the marking substance on the product can indicate that it is the original product inserted into the tamper-evident container, while the absence of the marking substance on a product removed from the tamper-evident container can indicate that the original product has been replaced in the tamper-evident container with a substitute.

Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-β1) are provided, particularly recognizing human and mouse TGF-β1 and not recognizing or binding TGF-β2 or TGF-β3. Particular antibodies are provided which specifically recognize and neutralize TGF-β1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-β1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-β1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.