A product preparation system and method for processing a container including a cup body and a cup closure assembly configured for removable operative engagement with the cup body, the cup closure assembly including a hinged spout cover and a user-removable multi-function restricting portion integrally formed as part of the cup closure assembly and detachable therefrom, the user-removable multi-function restricting portion being operative, when integrally attached to the cup closure assembly to prevent normal user opening of the hinged spout cover.

A lockable cigarette box has a slidable collar which slides upwards and links to a cover of the box to hold the cover closed in an embodiment of the disclosed technology. Further, a locking mechanism within the slidable collar which attaches to a front side of the cover keeps the cigarette box closed and locked at times. One can use a dial, button, or other input to set a time and/or to run a program which allows the box to opened only up to a certain amount of times per unit of time (rate) and/or a certain total number of times over the course of the program. This allows a person to control the maximum number of cigarettes removed over a period of time and how fast the cigarettes are removed.

Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-?1) are provided, particularly recognizing human and mouse TGF-?1 and not recognizing or binding TGF-?2 or TGF-?3. Particular antibodies are provided which specifically recognize and neutralize TGF-?1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-?1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-?1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.

A method for preventing tampering with a package includes: affixing a plurality of labels to a physical package, each label including a machine-readable code, the machine-readable code being encoded with a unique value that is unique across the machine-readable code included in each of the plurality of labels; reading, by a computing device, the machine-readable code included in each label of the plurality of affixed labels to obtain the encoded unique value; storing, in the computing device, a cryptographic key pair comprised of a public key and a private key; generating, by the computing device, a digital signature using the private key; and electronically transmitting, by the computing device, a data message to a node in a blockchain network, wherein the data message includes at least the generated digital signature, the public key, and the unique value read for each label of the plurality of labels.

A tape dispensing system includes packaging tape an application apparatus, and an incision element. The application apparatus is configured to apply the packaging tape to a package. The incision element defines a unique pattern, and is connected to the application apparatus. Movement of the apparatus is effective to punch or incise the unique pattern defined by the incision element completely through the packaging tape and into the package as or after the packaging tape is applied to the package.

A tamper evident closure comprises a cap having a plug, a skirt and a locking member. The cap and the skirt have seats in which a first portion and a second portion of the locking member are arranged. Upon first opening, as the cap moves longitudinally away from the skirt, the lower edge of the cap passes over the first portion longitudinally so that, upon reclosing the closure, the first portion positions in an obstructive manner between the lower edge of the cap and the upper edge of the skirt.

The invention relates to a closure for the pouring spout of a container, the closure comprising a closure cap (1) screwed onto the pouring spout (2) and comprising a tamper-indicating part (7) that, on unscrewing of the cap, bends away or breaks off or away when the closure cap (1) is unscrewed such that the tamper-indicating part (7) changes position relative to the closure cap (1), the outer surface of the tamper-indicating part (7) carrying information (8, 9) that is visible as long as the closure is in its unopened and intact condition and is no longer visible once the closure has been opened and the tamper-indicating part (7) has changed position.

The present invention is directed to a thermoplastic package includes a tray and a lidding film both of which are suitable for recycling into a polyethylene terephthalate (PET) recycling stream. Packages according to the present invention comprise predominantly amorphous polyethylene terephthalate (APET) relative to the total weight of the package. Another object of the present invention is to provide a package especially for retail display for containing a food such as fresh produce, cheeses and meats, and/or non-food product. Still another object of the present invention is to provide a manually openable package which includes a tray peelable heat sealed to a lidding film laminate.

A safety capsule for containers, comprising: an external cap (2), provided with coupling means for the coupling thereof to the neck (C) of a container; an internal element (3), located inside the external cap (2) and configured to be associated, in a removable manner, with an opening (A) of the container; connecting means (4, 5), interposed between the external cap (2) and the internal element (3), and structured so as to leave the external cap (2) and the internal element (3) unconstrained with respect to a movement for opening or removal of the external cap (2) between a closed position and an intermediate position, and solidly constrain the external cap (2) and the internal element (3) with respect to the movement for opening or removal of the external cap (2) between the intermediate position and an opening position; a signalling means (S) structured so as to take on a given configuration in the intermediate position.

The present invention relates to a closure device (1) for a container (2) in which a flowable material (3) is stored, comprising a base element (4), which can be fastened on a container opening (5) of the container (2), a spout (11) with a dispensing opening (7), whereby the spout (11) is positioned inboard of the base element (4), and a lid (8) connected to the base element (4) by a hinge (12), whereby the lid (8) can be moved back and forth between a closed position (9) in which the lid (8) closes the dispensing opening (7) so that the spout (11) is not accessible and an open position (10) in which the spout (11) is accessible, tamper evidence indication means (13) for visually indicating if the lid (8) of the closure device (1) has once been moved out of its closed position (9).