It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline technology are combined to realize the recrystallization of Cefuroxime Sodium. Processes such as extraction, adsorption, crystallization and drying are carried out with a supercritical fluid, a solvent, an extraction cell and a crystallization tank to realize the recrystallization of Cefuroxime Sodium under a specific pressure at a specific temperature.

Compositions and methods used in the modification of crystallization of aluminum hydroxide from liquor in an aluminum hydroxide production process, such as the Bayer process. More particularly, crystal growth modifier compositions comprising a component of crude corn oil derived from a bioethanol production process and/or a component of biodiesel and methods of using such compositions to modify particle size and distribution of precipitated alumina trihydrate in a precipitation liquor crystallization process.

Compositions and methods used in the modification of crystallization of aluminum hydroxide from liquor in an aluminum hydroxide production process, such as the Bayer process. More particularly, crystal growth modifier compositions comprising a component of crude corn oil derived from a bioethanol production process and/or a component of biodiesel and methods of using such compositions to modify particle size and distribution of precipitated alumina trihydrate in a precipitation liquor crystallization process.

Provided is a solvate of a compound (A) represented by the following formula and a method of manufacturing the solvate. A solvent forming the solvate includes a cyclic ether compound (B) having a carbon atom, an oxygen atom, and a hydrogen atom, which is 0.05 to 2.0 moles per mole of the compound (A).

##STR00001## X and Y represent an oxygen atom, a sulfur atom, a nitrogen atom, or a carbon atom, at least one of X or Y represents a nitrogen atom, Z represents an atom group that forms a 5- to 7-membered aromatic ring with XCCY, L.sup.1 and L.sup.2 represent an alkylene group having 2 to 4 carbon atoms, R.sup.3 to R.sup.6 represent a substituent, q, r, v, and w represent specific integers, in a case where v represents an integer of 2 to 4, a plurality of R.sup.5's are not linked to each other to form a ring.