An integrated upgrading process for upgrading a heavy oil, the process comprising the steps of introducing a heavy oil to a visbreaker unit; processing the heavy oil in the visbreaker unit to produce a visbreaker product stream; feeding the visbreaker product stream to a fractionator; separating the visbreaker product stream in the fractionator to produce a bottoms stream, a gas oil stream, a naphtha stream, and a gas product stream; feeding the bottoms stream to a supercritical water unit; and processing the bottoms stream in the supercritical water unit to produce an upgraded bottoms stream.

A substrate processing apparatus includes a supercritical fluid producing apparatus including a pump configured to send out a processing fluid; a processing container configured to perform a supercritical fluid processing on a substrate with a processing fluid in a supercritical state sent from the supercritical fluid producing apparatus; and a controller configured to control at least the supercritical fluid producing apparatus. When a pressure increase is performed within the processing container by using the processing fluid, the controller determines a first supply rate at which the processing fluid is supplied to the processing container based on a target time during which the pressure increase is performed, an amount of the processing fluid required for the pressure increase and a density of the processing fluid. Further, the supercritical fluid producing apparatus supplies the processing fluid to the processing container based on the first supply rate.

A source supplier includes a source reservoir that contains a liquefied source fluid for a supercritical process, a vaporizer that vaporizes the liquefied source fluid into a gaseous source fluid under high pressure, a purifier that removes organic impurities and moistures from the gaseous source fluid and an analyzer connected to the purifier that analyzes an impurity fraction and a moisture fraction in the gaseous source fluid. Moisture and organic impurities are removed from the source fluid to reduce the moisture concentration of the supercritical fluid in the supercritical process.

A method for purifying polybutylene terephthalate (PBT) includes: providing or receiving initial PBT, in which oligomers and tetrahydrofuran are present; dissolving the initial PBT in hexafluoroisopropanol (HFIP) to form a solution, in which the oligomers are also dissolved in the HFIP; and contacting the solution with compressed CO.sub.2 at a temperature and a pressure, thereby precipitating the purified PBT, resulting from a large portion of the oligomers are still dissolved in the HFIP, in the operation the temperature is in a range of 20 C. to 35 C., and the pressure is in a range of 900 psi to 1400 psi. A device for purifying PBT is also provided.

Polymorphic forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) and a metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) are disclosed and characterized. Compositions and method for treatment of Alzheimer's disease that includes the polymorphic forms and metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73).

An integrated upgrading process for upgrading a heavy oil, the process comprising the steps of introducing a heavy oil to a visbreaker unit; processing the heavy oil in the visbreaker unit to produce a visbreaker product stream; feeding the visbreaker product stream to a fractionator; separating the visbreaker product stream in the fractionator to produce a bottoms stream, a gas oil stream, a naphtha stream, and a gas product stream; feeding the bottoms stream to a supercritical water unit; and processing the bottoms stream in the supercritical water unit to produce an upgraded bottoms stream.

Polymorphic forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3 -furanmethanamine hydrochloride (ANAVEX2-73) and a metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) are disclosed and characterized. Compositions and method for treatment of Alzheimer's disease that includes the polymorphic forms and metabolite of tetrahydro-N,N-dimethyl-2,2 -diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73).

A method for purifying polybutylene terephthalate (PBT) includes: providing or receiving initial PBT, in which oligomers and tetrahydrofuran are present; dissolving the initial PBT in hexafluoroisopropanol (HFIP) to form a solution, in which the oligomers are also dissolved in the HFIP; and contacting the solution with compressed CO.sub.2 at a temperature and a pressure, thereby precipitating the purified PBT, resulting from a large portion of the oligomers are still dissolved in the HFIP, in the operation the temperature is in a range of 20 C. to 35 C., and the pressure is in a range of 900 psi to 1400 psi. A device for purifying PBT is also provided.

Polymorphic forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) and a metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) are disclosed and characterized. Compositions and method for treatment of Alzheimer's disease that includes the polymorphic forms and metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73).

It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline technology are combined to realize the recrystallization of Cefuroxime Sodium. Processes such as extraction, adsorption, crystallization and drying are carried out with a supercritical fluid, a solvent, an extraction cell and a crystallization tank to realize the recrystallization of Cefuroxime Sodium under a specific pressure at a specific temperature.