The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.

Described is a radial flow column for conveying a liquid product through an adsorber material, more particularly for radial flow chromatography, having a housing and, arranged therein, an inner and an outer screen, each of which surrounds a longitudinal axis of the housing and between which a radial intermediate space for receiving the adsorber material is formed. The end-face end regions of the inner and outer screen are sealed with respect to the housing in order to convey the product radially through the screens and the adsorber material. Because the radial flow column comprises ring seals for radially sealing the end-face end regions and the ring seals with corresponding sealing faces permit an axial play of the screens in the housing, production tolerances of the screens with respect to one another and in relation to the housing, and longitudinal fluctuations of the screens, can be compensated in a material-preserving manner.

Described is a radial flow column for conveying a liquid product through an adsorber material, more particularly for radial flow chromatography, having a housing and, arranged therein, an inner and an outer screen, each of which surrounds a longitudinal axis of the housing and between which a radial intermediate space for receiving the adsorber material is formed. The end-face end regions of the inner and outer screen are sealed with respect to the housing in order to convey the product radially through the screens and the adsorber material. Because the radial flow column comprises ring seals for radially sealing the end-face end regions and the ring seals with corresponding sealing faces permit an axial play of the screens in the housing, production tolerances of the screens with respect to one another and in relation to the housing, and longitudinal fluctuations of the screens, can be compensated in a material-preserving manner.

Disclosed are chromatography systems employing a releasable coupling (100) for holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner component (110) for accepting a fluid tubing (30), said inner component including a resiliently deflectable portion (118) arranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collar (130) having and internal through-aperture (132) for slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flange (134) extending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.

Disclosed are chromatography systems employing a releasable coupling (100) for holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner component (110) for accepting a fluid tubing (30), said inner component including a resiliently deflectable portion (118) arranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collar (130) having and internal through-aperture (132) for slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flange (134) extending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.

Devices for the separation of components within a fluid are disclosed herein. The device includes a housing that contains a roll of film with spaced apart microstructures thereon to crate channels to direct fluid flow. The channels have functionalized surfaces to attract and retain desired components in the fluid so that those components can be separated from the fluid. The film roll is typically contained by an outer sleeve around its perimeter to contain the fluid therein. The device also includes a central hub on which the film roll is mounted.

An alternating cascaded system for high-salinity wastewater treatment includes a pollutant removal system and an alternating cascaded water conveyance system embedded in the pollutant removal system. The pollutant removal system includes four partition plates, a pollutant removal zone and a discharge sump; and the alternating cascaded water conveyance system includes feed water distribution channels disposed under a feed water conveyer pipe and on an outer wall of a first pollutant removal subzone, cleaning water distribution channels disposed on an outer wall of a third pollutant removal subzone and located under a cleaning water pipe, and a purified water discharge pipe and a cleaning water discharge pipe that are located in the discharge sump and axially have a same discharge direction from top to bottom.

An alternating cascaded system for high-salinity wastewater treatment includes a pollutant removal system and an alternating cascaded water conveyance system embedded in the pollutant removal system. The pollutant removal system includes four partition plates, a pollutant removal zone and a discharge sump; and the alternating cascaded water conveyance system includes feed water distribution channels disposed under a feed water conveyer pipe and on an outer wall of a first pollutant removal subzone, cleaning water distribution channels disposed on an outer wall of a third pollutant removal subzone and located under a cleaning water pipe, and a purified water discharge pipe and a cleaning water discharge pipe that are located in the discharge sump and axially have a same discharge direction from top to bottom.

A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.