Integral chromatography unit having an inlet and an outlet, and comprising one or more membranes interposable in the internal volume of the unit between the inlet and outlet. In certain embodiments, each of the membranes is allotted adequate space within the unit to swell by the placement of one or more spacers. Fluid entering the unit through a fluid inlet passes the membrane(s) and spacer(s) prior to exiting the unit through a fluid outlet.

Integral chromatography unit having an inlet and an outlet, and comprising one or more membranes interposable in the internal volume of the unit between the inlet and outlet. In certain embodiments, each of the membranes is allotted adequate space within the unit to swell by the placement of one or more spacers. Fluid entering the unit through a fluid inlet passes the membrane(s) and spacer(s) prior to exiting the unit through a fluid outlet.

A socket unit for a capillary connection system, especially for use in HPLC applications, includes a housing with a housing outer surface and a housing inner surface that define a housing axial cavity. The socket unit also includes a socket connecting mechanism adapted to engage with a corresponding plug connecting mechanism of a plug unit to connect the plug unit and the socket unit together, wherein the socket connecting mechanism is adapted for a predetermined number of discrete connection states between the socket unit and the plug unit.

A socket unit for a capillary connection system, especially for use in HPLC applications, includes a housing with a housing outer surface and a housing inner surface that define a housing axial cavity. The socket unit also includes a socket connecting mechanism adapted to engage with a corresponding plug connecting mechanism of a plug unit to connect the plug unit and the socket unit together, wherein the socket connecting mechanism is adapted for a predetermined number of discrete connection states between the socket unit and the plug unit.

A fractal flow device comprising at least one fractal pack. The at least one fractal pack comprises at least two fractal cells, where each fractal cell comprises a fractal distributor, a chamber adjacent the fractal distributor, and a fractal collector adjacent the chamber. Methods of using the fractal flow device are also disclosed.

A chromatography device for removing a solute from a fluid is provided. The device has a first plate having an inlet and a first channel. The first channel directs the fluid from the inlet towards chromatographic media housed in a chamber coupled to the first plate. The chamber has a leading edge for receiving the fluid from the first channel and a trailing edge for delivering the fluid to a second channel. The chromatographic media is configured to remove the solute from the fluid as the fluid passes through the chamber. The device also has a second plate coupled to the chamber having the second channel and an outlet. The second channel directs the fluid from the chamber to the outlet. The direction of flow of fluid through the first channel and the second channel is transverse to a direction of flow of the fluid through the chromatographic media. A method of removing a solute from a fluid is also provided.

A chromatography device for removing a solute from a fluid is provided. The device has a first plate having an inlet and a first channel. The first channel directs the fluid from the inlet towards chromatographic media housed in a chamber coupled to the first plate. The chamber has a leading edge for receiving the fluid from the first channel and a trailing edge for delivering the fluid to a second channel. The chromatographic media is configured to remove the solute from the fluid as the fluid passes through the chamber. The device also has a second plate coupled to the chamber having the second channel and an outlet. The second channel directs the fluid from the chamber to the outlet. The direction of flow of fluid through the first channel and the second channel is transverse to a direction of flow of the fluid through the chromatographic media. A method of removing a solute from a fluid is also provided.

The invention relates to a method for manufacturing a multicapillary packing for an exchange of material including the formation, by a 3D printing method, of a monolith having a porous mass through which a plurality of parallel channels passes, opening on an inlet face and an outlet face of the packing, the 3D printing method being chosen among: selective laser sintering, molten wire deposition, stereolithography, binder spraying and spraying of material, the porous mass being suitable for allowing the diffusion of material to be exchanged between the channels.

A chromatography device having a housing having an inlet and an outlet. At least two layers of media disposed between the inlet and the outlet inside of the housing forming a media stack, with at least one of the layers comprising a functionalized layer. An optional spacer ring disposed between the two layers of media forming an air gap between them. A non-functionalized sealing layer disposed between the inlet and the outlet inside of the housing as the last layer of media in the media stack within the housing as a fluid passes from the inlet to the outlet through the media stack. A margin of the sealing layer in contact with the housing; the margin being compressed by the housing forming a compressive seal to prevent fluid from leaking to the outlet past the compressive seal.

A chromatography device having a housing having an inlet and an outlet. At least two layers of media disposed between the inlet and the outlet inside of the housing forming a media stack, with at least one of the layers comprising a functionalized layer. An optional spacer ring disposed between the two layers of media forming an air gap between them. A non-functionalized sealing layer disposed between the inlet and the outlet inside of the housing as the last layer of media in the media stack within the housing as a fluid passes from the inlet to the outlet through the media stack. A margin of the sealing layer in contact with the housing; the margin being compressed by the housing forming a compressive seal to prevent fluid from leaking to the outlet past the compressive seal.