This present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process of preparing highly concentrated antibody compositions. and highly concentrated antibody products.

Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced.

Provided herein are methods of processing a fluid comprising a recombinant therapeutic protein that include the use of a bioprocessing system comprising integrated unit operations, including cell removal, cell retention, chromatography, virus inactivation, virus filtration, TFF, and formulation. Also provided are bioprocessing systems that include these unit operations.

A filtering device for obtaining a chemical liquid by purifying a liquid to be purified has an inlet portion, an outlet portion, a filter A, at least one filter B different from the filter A, and a flow path which includes the filter A and the filter B arranged in series between the inlet portion and the outlet portion and extends from the inlet portion to the outlet portion, in which the filter A has a porous base material made of polyfluorocarbon and a coating layer which is disposed to cover the porous base material and contains a first resin having a hydrophilic group.

A filtration system includes at least one spiral wound first filter section in fluid communication with at least one spiral wound second filter section. The first and second filter sections include: (i) a filtration membrane; (ii) a feed spacer located adjacent the filtration membrane and defining a feed flow channel; and (iii) a permeate spacer located adjacent the filtration membrane and defining a permeate flow channel. A thickness of the feed flow channel in the first filter section is different than a thickness of the feed flow channel in the second filter section, and/or an effective volume of the first filter section is different than an effective volume of the second filter section. A method of filtering a feed flow is also disclosed.

The present disclosure provides a method and a system for extracting long chain dicarboxylic acid, the method comprising: (1) subjecting a long chain dicarboxylic acid fermentation broth to a primary membrane filtration treatment to give a first filtrate; subjecting the first filtrate to decolorization, acidification/crystallization, and solid-liquid separation treatments to give a first solid; (2) mixing the first solid, a base and water to form a solution; subjecting the solution to a secondary membrane filtration treatment to give a second filtrate; subjecting the second filtrate to decolorization, acidification/crystallization, and solid-liquid separation treatments to give a second solid; and (3) mixing the second solid and water to form a mixture; subjecting the mixture to a thermostatic treatment at 105-150° C., followed by cooling for crystallization and solid-liquid separation treatment. By the method, the resulted long chain dicarboxylic acid product has a high purity and no residual organic solvent.

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

A porous membrane includes a modacrylic copolymer. The modacrylic copolymer includes, with respect to 100 parts by mass of all structural units constituting the modacrylic copolymer, 15 to 85 parts by mass of a structural unit derived from acrylonitrile, 15 to 85 parts by mass of a structural unit derived from at least one halogen-containing monomer selected from the group consisting of vinyl halide and vinylidene halide, and 0 to 10 parts by mass of a structural unit derived from a vinyl monomer having an ionic substituent. The porous membrane can be produced by preparing a modacrylic copolymer solution by dissolving the modacrylic copolymer in a solvent, and bringing the modacrylic copolymer solution into contact with a non-solvent for the modacrylic copolymer such that the modacrylic copolymer solution is solidified.

A desalination system includes a desalination platform, a first skid disposed on a first deck of the desalination platform, the first skid including at least one of a first filtration unit configured to produce a first filtrate stream, and a first permeate unit configured to produce a first permeate stream, a first interconnecting pipework coupled to the first skid, and a first pipework support disposed on the first deck, wherein the first interconnecting pipework is disposed on the first pipework support.

The present disclosure relates, according to some embodiments, to systems for purifying proteins and carbohydrate rich products from photosynthetic aquatic species and compositions thereof. In some embodiments, a system for recovering a highly soluble protein product from a biomass comprising a microcrop (e.g., Lemna) may comprise (a) a lysing unit to lyse a first portion of the biomass to form a first portion of lysed biomass, (b) a first separating unit to separate the first portion of lysed biomass to generate a first portion of a juice fraction and a first portion of a solid fraction, (c) a second separating unit to separate the first portion of the juice fraction to generate a first portion of a first juice and a first portion of a first cake, (d) a first filtration unit to filter the first portion of the first juice to generate a first portion of a soluble protein and a first reject stream, (e) a second filtration unit to filter the first portion of the soluble protein to generate a first portion of a second soluble protein and a second reject stream, (f) a dewatering unit to concentrate the first portion of the second soluble protein to generate a first portion of a concentrated soluble protein, and (g) a drying unit to dry the first portion of the concentrated soluble protein to generate a first portion of a dry protein concentrate.