The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

A potting material as for use in membrane separation modules maybe provided consisting of a tin alloy having a melting point of from 210 to 230 C., wherein the tin alloy consists, on a metals basis, of: from 95 to 97 wt. %; and from 3 to 5 wt. % of the combination of Silver (Ag) with at least one of Nickel (Ni), Copper (Cu), or Germanium (Ge).

A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter d.sub.1 of the hollow fiber membrane 31 is equal to or smaller than 150 m, a tilt angle with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60, and a ratio D.sub.1/L of an outer diameter D.sub.1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.

A hollow fiber fluid separation device includes a hollow fiber cartridge, comprising a plurality of hollow fiber membranes arranged around a central tubular core, a first tubesheet and a second tubesheet encapsulating respective distal ends of the hollow fiber bundle. The tubesheets have boreholes in fluid communication with bores of the hollow fiber membrane. In at least one of the tubesheets, the boreholes are formed radially and are in communication with the central tubular core. The hollow fiber fluid separation device can be utilized in liquid separation applications such as ultrafiltration and in gas separation processes such as air separation. The design disclosed herein is light weight and compact and is particularly advantageous at high operating temperatures when the pressure of the feed fluid introduced into the bores of hollow fibers is higher than the pressure on the shell side of the device.

A method for potting hollow fiber membranes comprises the steps of forming a bundle of membranes with a layer of adhesive; covering one end of the bundle with a permeate pan, the ends of the membranes protruding upwards into the permeate pan; and flowing a liquid potting material into the permeate pan. The bundle may be tilted to more quickly distribute the liquid potting material. An apparatus for filtering liquid with hollow fiber membranes comprises a bundle of membranes, a layer of adhesive spaced from the end of the bundle, a permeate pan covering the end of the bundle, and a header formed with the membranes, the adhesive and the pan.

A water filtration module (10) is made of hollow fibers for filtration from the outside to the inside of the fibers, wherein the fibers are arranged inside a casing (11) made of multiple elements (20). The module (10) and at least one element (20) include elements working together, which are designed to enable the element (20) to be mounted in the module (10) in a removable manner.

Disclosed are a hollow fiber membrane module, a filtration apparatus based on the same, and a method for manufacturing the filtration apparatus. The hollow fiber membrane module includes two headers respectively provided with a permeate collecting unit therein, wherein each of the headers has grooves on its two sides, the grooves being extended in a length direction of the hollow fiber membrane. Since one slide rod can simultaneously be inserted into grooves of two adjacent hollow fiber membrane modules, the hollow fiber membrane modules can mutually serve as guides for insertion/ejection thereof. Also, since the grooves formed on the header can serve as insertion holes into which a clamp is inserted, the clamp can be used for coupling between the hollow fiber membrane module and another element and reinforcement of the coupling.

Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37 C. through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/m.sup.2 or less: (A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and (B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more. The present invention provides a hollow fiber membrane module including a hollow fiber membrane containing a polysulfone-based polymer and a hydrophilic polymer built therein, which elutes little eluted substance and exhibits high biocompatibility, while change in performance due to crosslinking of the hydrophilic polymer is suppressed.

The present disclosure relates to a process and a device for winding a strand of hollow fiber membranes.

An array of hollow fibers including a plurality of hollow fibers of a predetermined diameter configured to receive a gas having oxygen therein and transfer the oxygen to a fluid and/or transfer carbon dioxide in the fluid to a gas. The array is configured in a predetermined pattern having a predetermined packing density that is a fraction of a total cross-sectional area of the array occupied by the hollow fibers.