A filtration module is provided, the module including at least one filtration packet containing filtration media or one or more membranes, such as a stack of membranes, the at least one filtration packet having one or more fluid ports, the one or more fluid ports being surrounded by a primary seal and a secondary seal spaced from the primary seal. The secondary seals are designed to maintain sterility of the assembly during shipping, handling and/or installation. A removable film may cover one or more fluid ports to maintain sterility prior to use.

An example separation system includes a stack of membrane plate assemblies. An example membrane plate assembly may include membranes bonded to opposite sides of a spacer plate. The spacer plate may include a first opening in fluid communication with a region between the membranes, and a second opening in fluid communication with a region between membrane plate assemblies. Adjacent membrane plate assemblies in the stack may have alternating orientations such that bonding areas for adjacent membranes in the stack may be staggered. Accordingly, two isolated flows may be provided which may be orthogonal from one another.

This invention relates generally to a filtration process and apparatus for separating valuable or harmful process liquids from mixtures or slurries that contain such liquids and solid particles. In particular, the invention relates to a filtration process for separating Process Liquid from a feed slurry that comprises a mixture of the Process Liquid and solid particles, the process employing a Sweep Liquid that is less dense than the Process Liquid.

The invention relates to a modular flow system having a plurality of frame elements (101, 102) configured to be combined together to form a stack for forming a functional member. This functional member may be in particular a membrane distillation stage, a vapor generator, a condenser, a heat exchanger, a filter and/or a pervaporation stage. The frame elements (101, 102) each include: ⋅ an outer frame (39) and an inner frame (43), the inner frame (43) encasing a central inner region (40) and being surrounded by the outer frame (39), and ⋅ passage openings (13 to 16) and vapor and/or liquid channels (17, 18) arranged between the outer frame (39) and the inner frame (43). At least one of the two vapor and/or liquid channels (17, 18) is connected to the central inner region (40) by at least one vapor and/or liquid channel opening (22) constituting a through hole in the inner frame. In the frame elements (101, 102), when combined together to form the modular flow system, the vapor and/or liquid channels (17, 18) are arranged above the inner region (40).

The invention relates to a modular flow system having a plurality of frame elements (101, 102) configured to be combined together to form a stack for forming afunctional member such as in particular a membrane distillation stage, a vapor generator, a condenser, a heat exchanger, a filter and/or a pervaporation stage, wherein the frame elements (101, 102) each include: an outer frame (39) and an inner frame (43), the inner frame (43) encasing a central inner region (40) and being surrounded by the outer frame (39), passage openings (13 to 16) and vapor and/or liquid channels (17, 18) arranged between the outer frame (39) and the inner frame (43), wherein at least one of the vapor and/or liquid channels (17, 18) comprises at least one internal strut member (48) extending between the inner frame (43) and the outer frame (39).

The invention relates to a modular flow system having a plurality of frame elements (101, 102) configured to be combined together to form a stack for forming a functional member such as in particular a membrane distillation stage, a vapor generator, a condenser, a heat exchanger, a filter and/or a pervaporation stage, wherein the frame elements (101, 102) each include: an outer frame (39) and an inner frame (43), the inner frame (43) encasing a central inner region (40) and being surrounded by the outer frame (39), at least one first passage opening (13 to 16) arranged between the outer frame (39) and the inner frame (43) and separated from the central inner region (40) by a frame wall on a first and/or opposite second frame side of the inner frame (43), and at least one liquid passage (45, 46) provided by the frame wall and configured to distribute a liquid from the first passage opening (13) to a feeding area (40′) and/or to collect a liquid from the feeding area (40) to the first passage opening (16a, 16b)), the feeding area (40′) being aligned with the central inner region (40) but being outside and/or in front of the inner frame (43), wherein the liquid passage extends asymmetrically and/or discontinuously along the first and/or second frame side.

Tangential flow filtration systems utilizing flexible bags for permeate collection are provided.

A filter system (100) for biopharmaceutical processes includes: at least one filter unit (10); and at least one distributor plate (200), against which the filter unit rests. A tubeless distributor unit (202) is arranged within the distributor plate and is fluidically connected to the filter unit. The distributor unit guides the fluid to be filtered to the filter unit and/or receives and discharges the filtered fluid from the filter unit. The distributor unit includes at least one active control element (232; 238), with which a fluid flow (14) through the distributor unit) and the filter unit is controlled in an open loop flow or a closed loop flow. The fluid connection between the filter unit and the distributor plate is tubeless. Also provided are a distributor plate (200) for a filter system (100) for biopharmaceutical processes and a method for producing a filter system (100) for biopharmaceutical processes.

A disc tube reverse osmosis module is provided. In various embodiments, deflector disc assemblies and associated membranes are sequentially alternately disposed from top to bottom. The upper flange is in sealing connection with the central pull rod, the upper lock nut is in threaded connection with an upper end of the central pull rod and located above the upper flange, the yielding water collecting pipe sleeves the central pull rod and is in sealing connection with a lower side of the lower flange, the lower lock nut is in threaded connection with a lower end of the central pull rod, an end of the yielding water receiving pipe is fixedly connected to the yielding water collecting pipe, an inner surface of the shell is respectively in sealing connection with the upper flange and the lower flange, and the water inlet receiving pipe and the concentrated liquid receiving pipe are fixed to the lower flange.

An implantable or wearable kidney enclosure that is cylindrical, ovoid, or otherwise non-angular e.g., not rectangular or cuboid), having a circular or oval hemofilter that provides a blood flow pattern from an internal, central artery source radially outwards. Due to the efficient flow of the circular filter design, the enclosure can be made in a cylindrical low profile shape, resulting in a compact enclosure highly suitable for implantable and wearable dialysis applications.