A high velocity cross flow dynamic membrane filtration system disc membrane assembly includes a frame having first and second end members and a plurality of rails extending between the first and second end members. At least two parallel support shafts are coupled to the frame, each support shaft defining a longitudinal axis about which is positioned a plurality of axially spaced membrane discs. The plurality of membrane discs associated with one of the at least two parallel support shafts is interspersed between the plurality of membrane discs associated with another of the at least two parallel support shafts. Each rail of the plurality of rails is configured to be received by a mounting rail within a vessel defining a treatment chamber. A permeate tube is coupled to each support shaft and in fluid communication with the membrane discs associated with that support shaft.

Fluid treatment assemblies comprising a plurality of adjustable tensioning rod assemblies comprising tensioning rods having a tensioning nut and a locking nut threadably attached to the tensioning rods, and methods of adjusting the tension on the assemblies, are provided.

A laminate is provided comprising at least one polysulfone and/or polyethersulfone porous membrane heat bonded to a polyvinylidene fluoride substrate.

A laminate is provided comprising at least one polysulfone and/or polyethersulfone porous membrane heat bonded to a polyvinylidene fluoride substrate.

A reverse osmosis system includes a multi-element membrane array having a plurality of membrane elements disposed in series and a plurality of permeate pipes receiving permeate from a respective one of the plurality of membrane elements. Each of the plurality of elements has an inlet and an outlet. A plurality of connectors coupling successive permeate pipes together. Each of the plurality of connectors includes one of a plurality of flow restrictors. Each of the plurality of flow restrictors is sized to further restrict permeate flow into a subsequent permeate pipe of the plurality of permeate pipes.

Methods and devices are disclosed for a separation device. A separation device includes a separation module having a separation membrane separating an interior of the separation module into a retentate compartment and a permeate compartment. The retentate compartment includes at least one retentate channel, a feed port fluidly coupled to the at least one retentate channel and a retentate port. The permeate compartment includes at least one permeate channel disposed within the permeate compartment and a permeate port fluidly coupled to the at least one permeate channel. a retentate collector fluidly connected to the retentate port. The device further includes a feed reservoir, a permeate reservoir, a fluidic gate located between the feed reservoir and the separation module, a vent located between the retentate channel and the permeate channel end adjacent the retentate port and a pressure differential source applied across the separation module.

Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

A method of operating a high velocity cross flow dynamic membrane filtration includes feeding a fluid stream into a pressure vessel, in which the vessel defines a treatment chamber containing a disc membrane assembly having a first support shaft and a second support shaft, each support shaft defining a longitudinal axis about which is positioned a plurality of axially spaced membrane discs. The method further includes distributing the fluid stream over at least a portion of the disc membrane assembly. The method also includes discharging a first portion of the fluid stream from the vessel and discharging a second portion of the fluid stream from the vessel. The method additionally includes rotating the first support shaft and the second support shaft in a first direction. The rotating includes modulating a rotation rate in response to the flow rate of the second portion of the fluid stream.

Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

A crossflow filtration unit for continuous diafiltration of a feed fluid for obtaining a retentate and a permeate, a corresponding method for diafiltration and the use of the crossflow filtration unit are provided. The crossflow filtration unit includes a diafiltration channel, a flat first filter material, a retentate channel, a flat second filter material, and a permeate collection channel, arranged such that the flat first filter material delimits the diafiltration channel and the retentate channel from one another, and the flat second filter material delimits the retentate channel and the permeate collection channel from one another. The diafiltration channel is fluidly connected to at least one inlet for the diafiltration medium, the retentate channel is fluidly connected to at least one inlet for the feed fluid and to at least one outlet for the retentate. The permeate collection channel is fluidly connected to at least one outlet for the permeate.