A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.

A filtration cell (10) for a biological sample including an upper chamber for receiving the biological sample to be filtered, a lower chamber in fluid communication with the upper chamber, and a filtration membrane (14) positioned between the upper chamber and the lower chamber is disclosed. A surface of the filtration membrane has a contact angle >90°. The flow of the biological sample through the upper chamber may be tangential to the filtration membrane and a filtrate passing through the filtration membrane may be collected in the lower chamber. Also, a method of filtering a biological sample including passing the biological sample through an upper chamber of a filtration cell as described above and collecting a filtrate in the lower chamber is disclosed.

A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.

A substrate for a liquid filter, which includes a polyolefin microporous membrane, the polyolefin microporous membrane having a water permeation efficiency of 0.51 to 1.20 ml/min.Math.cm.sup.2, the polyolefin microporous membrane having a bubble point of 0.45 MPa or more and 0.70 MPa or less, the polyolefin microporous membrane having a compressibility of less than 15%.

A substrate for a liquid filter, which includes a polyolefin microporous membrane, the polyolefin microporous membrane having a water permeation efficiency of 1.21 to 2.90 ml/min.Math.cm.sup.2, the polyolefin microporous membrane having a bubble point of 0.40 MPa to 0.65 MPa, the polyolefin microporous membrane having a compressibility of less than 15%.

A membrane including a polymer substrate having pore channels and a metal-organic framework disposed on the polymer substrate. Methods of producing the membrane are described. Methods of separating gases using the membrane are also provided.

There is provided a carbon capture mixed matrix membrane comprising: a polymeric support layer; and a carbon dioxide capture layer in contact with the polymeric support layer, the carbon dioxide capture layer comprising solid porous material with at least one carbon dioxide adsorption site, wherein the polymeric support layer comprises spatially ordered uniform sized pores. The polymeric support layer may be patterned by micro-molding, nanoimprinting, mold-based lithography or other suitable lithographic process. The carbon dioxide capture layer may comprise amine-functionalised material, metal-organic frameworks such as zeolite imidazolate framework 8 (ZIF-8) or copper benzene-1,3,5-tricarboxylate (Cu-BTC) which may or may not be amine modified. There is also provided a membrane module comprising at least one carbon capture mixed matrix membrane and a method of forming the carbon capture mixed matrix membrane.

A method providing direct access to porous three-dimensionally (3D) continuous polymer network structures and shapes by combining BCP-resol co-assembly with CO.sub.2 laser-induced transient heating. The CO.sub.2 laser source transiently heats the BCP-directed resol hybrid films to high temperatures at the beam position, inducing locally controlled resol thermopolymerization and BCP decomposition in ambient conditions. This enables shaping of BCP-directed porous resin structures with tunable 3D interconnected pores in a single process. Pore size can be varied from 10 nm to about 600 nm.

Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

Provided herein are methods of forming and optimizing cured features on a surface including controlling the surface upon which the cured features are applied. Additionally, a system for forming and processing the topographical features on the membrane is also described, along with mechanical features at specific system stations. More particularly, provided herein are methods of forming and optimizing topographical features applied to a membrane surface by controlling the membrane surface and by controlling the direction and magnitude of pressure applied to the membrane (substrate), as well as initially partially curing the topographical features, followed by fully curing of the topographical features to form the membrane having topographical spacing features formed thereon.