A fluid circuit includes a plurality of tubing segments and a plurality of operative components. Each tubing segment includes i) a non-conductive polymer portion defining a fluid passageway and ii) one or more interior conductive fluoropolymer stripes extending axially to the ends of each of the respective tubing segments. Each operative component includes a conductive fluoropolymer that extends between a plurality of tubing connector fittings forming a part of the fluid circuit, wherein each of the tubing connector fittings conductively connect the respective conductor of the operative component to the interior conductive fluoropolymer stripes of the tubing segment to provide a path to ground that extends through each operative component and each tubing segment.

The invention relates to a filter device for the exchange of substances, comprising a pipe section-shaped housing with a center of gravity and with two housing ends, in which housing a hollow fiber bundle consisting of semi-permeable membranes is arranged, comprising, furthermore, an end cap having a first and second opening, wherein the housing and the end cap configure a first sealing surface which connects the housing and the end cap sealingly, and wherein the first sealing surface is spaced apart further from the center of gravity of the housing than the aperture, and wherein a first fluid chamber is formed between the first sealing surface and the first opening of the end cap, via which first fluid chamber the first opening is connected to the first flow chamber, wherein the housing and the one end cap configure a second sealing surface, wherein the first and second sealing surface are not configured by way of a sealant.

A dialyzer and a fabricating method thereof are provided. The dialyzer includes a housing, a hydrophilic layer, a fixing layer, a plurality of hollow fiber membranes, and two end caps. The housing has a first opening and a second opening, and is provided with a dialysate inlet and a dialysate outlet, wherein an entire peripheral surface of the housing located between the first opening and the dialysate inlet is a first portion, and an entire peripheral surface of the housing located between the second opening and the dialysate outlet is a second portion. The hydrophilic layer is disposed on the inner wall of the first portion and the second portion, wherein the hydrophilic layer and the housing are different materials. The fixing layer is disposed on the hydrophilic layer and fixes the hollow fiber membranes to the inner wall of the housing.

An end cap of a dialyzer and a fabricating method thereof, and a dialyzer are provided. The end cap includes a main body and a sealing element. The main body has a blood port. The sealing element is integrally connected on an inner wall of the main body.

A hollow fiber membrane module includes: a tubular container accommodating a hollow fiber membrane bundle; headers, and potted parts. The header includes a header protrusion that protrudes in an annular shape toward the tubular container. The tubular container includes double annular protrusions, which are an inner protrusion and an outer protrusion protruding toward the header. The header and the tubular container are welded together by ultrasonic welding, with the header protrusion being inserted between the inner protrusion and the outer protrusion of the tubular container. The header protrusion and the inner protrusion of the tubular container are welded together at least in one or more regions, and the header protrusion and the outer protrusion of the tubular container are welded together at least in one or more regions.

The hollow fiber membrane module according to the present application is provided with a cylindrical container open at one end and the other end, a bundle of hollow fiber membranes packed in the cylindrical container, potting parts embedding and fixing the bundle of hollow fiber membranes at both ends of the cylindrical container, and headers provided at both ends of the cylindrical container and having nozzles that constitute an inlet and outlet for a fluid. In this hollow fiber membrane module, the headers and the cylindrical container are welded in at least two areas including a primary weld and a secondary weld, and the secondary weld is located in a position where welding is initiated after or simultaneously with the beginning of welding of the primary weld.

A water filtration system utilizes a housing configured to utilize various types of filter media and having a press-sealed closing system. The closing system includes a head portion defining a head opening, a lock member, and a lid member. The lock member releasably engages the head portion such that an abutment section of the lock member projects into the head opening. The lid member is received by the head portion to cover the head opening, and has an outward-facing press section configured to abut an inward facing portion of the abutment section of the lock member when the lid member is covering the head opening. Pressure generated within the housing during water filtration presses the lid member in an outward direction and causes the lid member press section to press against the abutment section of the lock member to substantially prevent disengagement of the lock member from the head portion.

Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.

A hollow fiber membrane blood purifying device including a cylindrical container, a hollow fiber membrane bundle, a potting resin fixing portion embedding and fixing the hollow fiber membrane bundle at each end of the cylindrical container, headers having nozzles, and ports further has the structure in which each header and the cylindrical container are welded in at least two regions over the circumference. The inside face of the header is in contact with a potting resin fixing portion cut face that is formed by cutting an outer side portion of the potting resin fixing portion in the length direction of the cylindrical container than the end face of each end of the cylindrical container, and the potting resin fixing portion cut face is in a compressively deformed state.

A membrane-based separation device comprises multiple interconnected flat sheets of membrane bonded to a flexible film. The bonded films are bonded in a way to create an accordion or zig-zag shape. In certain embodiments, the first or upstream layer is affixed to a suitable housing, and the last or most downstream layer is also affixed to the suitable housing. The housing may contain an inlet port for the introduction of sample, and an outlet port for the removal of filtered sample. Flow through the segments is in parallel. Since the membranes are not folded or pleated, higher performance membranes (e.g., polysulfone based membranes with some degree of asymmetry) than those usable in pleated or folded systems can be used.