A thermokinetic mixer for melt mixing plastics waste includes a housing enclosing a mixing chamber, and a shaft protruding through the mixing chamber and connectable to a drive unit. In the mixing chamber, Y-shaped mixing blades protrude radially from the shaft, wherein the free end of the mixing blades protruding into the mixing chamber is cuboid, and the end opposite the free end of the mixing blades has two legs in each case having at least one through bore. The shaft has polygonal recesses, in which recesses the legs can be fastened by a fastener protruding through the through bores.

A detachable rib for use in a mixing bowl that provides an obstacle for ingredients being driven around the inside of a mixing bowl. The rib comprises a blade configured to extend in an axial direction along an inner surface of the mixing bowl; and an attachment formation for engaging with a corresponding formation of the mixing bowl, the engagement securing the rib against circumferential movement in at least one rotational direction; such that in use the blade interrupts a path of food being driven around the mixing bowl.

A method for operating a bioreactor includes passing a drive shaft into a first tubular connector and a second tubular connector projecting from the first tubular connector, the first tubular connector and the second tubular connector being at least partially disposed within a container, the first tubular connector being more flexible than the second tubular connector, the second tubular connector having a length that comprises at least 20% of a combined length of the first tubular connector and the second tubular connector. Rotating the drive shaft so as to rotate the first tubular connector and the second tubular connector within the container.

A vane for an impeller of an agitator includes a socket having a base plane configured to mount the vane to an impeller, and a blade configured to mix a process fluid, the blade having a leading edge, a trailing edge, and a blade tip extending from the leading edge to the trailing edge at an end of the blade facing away from the socket, the blade having a pressure side and a suction side, and the pressure side having a first concave region towards the leading edge, a second concave region toward the trailing edge and a convex region between the first and second concave regions.

A small-scale, batch-wise device to simulate high-shear, short-duration emulsification of fluids from various industrial processes at elevated temperatures and pressures for the purpose of determining the quality and stability of those emulsions under different conditions and with different additives. A threaded, transparent tube capable high temperature and pressure is fitted with a threaded bearing with a shaft sealed gas tight at two points with spring-loaded, internally-facing, open rings. A socket head on the external end of the shaft held on a high-speed motor-drive rotates mixing blades on the internal end of the shaft. Process fluids and additives are added to the tube with a vaporizing liquid. The tube is sealed, heated to the process temperature under pressure, then inverted onto the motor drive, by which the blades are rotated at high-speed for a short duration. The tube is righted and the emulsion observed over time at process temperature under pressure.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

A fluid mixing system includes a container, such as a flexible bag, bounding a compartment. A flexible drive line is disposed within the compartment, the drive line having a first end rotatably connected to a first end of the container and an opposing second end rotatably connected to a second end of the container. At least one mixing element, such as an impeller, is coupled with the flexible drive line. Rotation of the drive line facilitates rotation of the impeller within the container.

A mixing impeller (10) for mixing a sealant inside a cartridge (1) is disclosed. The mixing impeller (10) comprises a central hub (11) and at least two mixing arms (20) extending radially outward from the central hub (11). Each of the mixing arms (20) may include a leading edge (24), a trailing edge (26), and a wiping edge (28) extending circumferentially between a leading tip (25) of the leading edge (24) and a trailing edge transition (27) of the trailing edge (26). The wiping edge (28) may have an arc length defining a wiping edge (28) angle, the leading tip (25) may be circumferentially offset in a direction of rotation of the mixing impeller (10) defining a leading edge (24) angle to provide a forward swept configuration, and the wiping edge (28) angle may be greater than the leading edge (24) angle. A sealant cartridge (1) and mixing impeller (10) assembly is also disclosed.

The disclosure provides for improved pharmaceutical compositions containing vemurafenib and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.

An apparatus is disclosed for mixing substances, such as paint. The apparatus includes an elongate member with a plurality of openings formed within it. A filament is threaded through the openings creating bights between openings. The bights and ends of the filament sweep through the substance when the elongate member is rotated, which works to mix the substance.