This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

A method for crystallizing calcium nitrate from an aqueous calcium nitrate composition including from 6 to 12 weight % nitric acid, from 11 to 17 weight % phosphoric acid, and from 36 to 49 weight % dissolved calcium nitrate, which aqueous composition is optionally directly obtainable from digesting phosphate rock in nitric acid. The method includes filling at least one vertical crystallizing tank through an inlet with the aqueous calcium nitrate composition. The crystallizing tank includes a vertical cylindrical section, a first inlet, a first outlet, a second inlet, three concentric banks of cooling coils, an agitator, and a temperature measurement device. The method includes circulating through the banks of cooling coils a cooling fluid, having an initial temperature ranging from 40 C. to 5 C., and rotating the agitator such that a minimum average heat transfer of 400 W/m.sup.2.Math.K is achieved on the cooling coil the most distant from the agitator.

The present invention relates to a stirrer having grooves formed on the inside of a container in order to improve the degree of mixing, and the stirrer which is provided comprises: a plurality of projections formed on the inner surface of a stirrer container; and a plurality of grooves formed between the plurality of projections.

The invention relates to an emulsification device for continuously producing emulsions, nano-emulsions, and/or dispersions having a liquid crystalline structure, comprising a) at least one mixing system, b) at least one drive for the stirring element, and c) at least one delivery unit for each component or each component mixture.

The invention relates to an emulsification device for continuously producing emulsions, nano-emulsions, and/or dispersions having a liquid crystalline structure, comprising a) at least one mixing system, b) at least one drive for the stirring element, and c) at least one delivery unit for each component or each component mixture.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.