The disclosure describes methods and devices with which to process and analyze difficult chemical, biological, environmental samples including but not limited to those containing bulk solids or particulates. The disclosure includes a cartridge which contains a separation tube as well as one or more valves and cavities for receiving raw sample materials and for directing and containing various fluids or samples. The cartridge may contain a separation fluid or density medium of defined density, and structures which direct particulates toward defined regions of the cartridge. Embodiments can include a rotational device for rotating the cartridge at defined rotational rates for defined time intervals. Embodiments allowing multiple assays from a single sample are also disclosed. In some embodiments, this device is used for direct processing and chemical analysis of food, soil, blood, stool, motor oil, semen, and other samples of interest.

Examples include microfluidic devices. Example microfluidic devices comprise a first microfluidic channel, a second microfluidic channel, and microfluidic output channel fluidly coupled to the first microfluidic channel and the second microfluidic channel via a fluid junction. The example device comprises a first fluid actuator disposed in the first microfluidic channel to actuate to thereby pump a first fluid into the microfluidic output channel, and the example device comprises a second fluid actuator disposed in the second microfluidic channel to actuate to pump a second fluid into the microfluidic output channel. The first fluid actuator and the second fluid actuator are to actuate to thereby pump a fluid mixture of the first fluid and the second fluid into the microfluidic output channel.

In one embodiment, a mixing device includes a sleeve that forms an inner space configured to receive a sample container, a housing associated with the sleeve, a mixing element contained within the housing that is configured to mix liquid contained within the sample container, and an activation element configured to activate the mixing element when the activation element is triggered.

An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a valve including a valve housing and a valve structure located within the valve housing. The valve structure can be configured to permit fluid to flow through the valve when in an open position, and can include a gravity wall wherein, when the valve structure is in the open position, fluid moving through the valve structure moves upward against a force of gravity when travelling through the valve and traversing the gravity wall.

A reactor microplate that allows for a researcher to perform a multitude of experiment in micro-gravity without risking potential exposure. The microplate includes a planar housing and an at least one chamber-mixing assembly. The chamber-mixing assembly includes a first retaining mechanism, a second retaining mechanism, a mixing channel, and an activation valve. The first retaining mechanism and the second retaining mechanism house solutions for an experiment and are positioned offset to each other, across the planar housing. The mixing channel fluidly couples the first retaining mechanism to the second retaining mechanism. Specifically, the mixing channel traverses into the planar housing from the first retaining mechanism to the second retaining mechanism. The activation valve is mechanically integrated in between the first retaining mechanism, the mixing channel, and the second retaining mechanism to control the flow of fluids in between the first retaining mechanism and the second retaining mechanism.

The present invention provides a fluidic device in which solutions of different concentrations can be easily obtained. The fluidic device includes: a first substrate and a second substrate which are stacked in a thickness direction; an undiluted solution introduction flow path which has an undiluted solution introduction port and which is constituted of a groove part provided on at least one of the first substrate and the second substrate; a first circulation flow path which is constituted of a groove part having an annular shape and having a shared part that shares part of a flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; a second circulation flow path which is provided independently of the first circulation flow path and which is constituted of a groove part having an annular shape and having a shared part that shares some flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; and/or a third circulation flow path which is constituted of a groove part having an annular shape and having a shared flow path that shares part of a flow path with the first circulation flow path and a non-shared flow path which is not shared with the first circulation flow path and which is connected to a diluting solution introduction port, wherein the undiluted solution introduction flow path includes a valve at both ends of the shared part.

According to one embodiment, a fluid controller includes a fluid channel deforming portion and a mixing portion provided downstream from the fluid channel deforming portion. The fluid channel deforming portion includes an upstream end portion, a first channel, a second channel and a channel terminating portion. At least one of the first and second channels is deformed between the upstream end portion and the channel terminating portion. A region of the second channel in a second cross-section, is increased more than a region of the second channel in the first cross-section, between the upstream end portion ad the channel terminating portion. The mixing portion mixes a plurality of fluids flowing through the fluid channel deforming portion.

The disclosure describes methods and devices with which to process and analyze difficult chemical, biological, environmental samples including but not limited to those containing bulk solids or particulates. The disclosure includes a cartridge which contains a separation tube as well as one or more valves and cavities for receiving raw sample materials and for directing and containing various fluids or samples. The cartridge may contain a separation fluid or density medium of defined density, and structures which direct particulates toward defined regions of the cartridge. Embodiments can include a rotational device for rotating the cartridge at defined rotational rates for defined time intervals. Embodiments allowing multiple assays from a single sample are also disclosed. In some embodiments, this device is used for direct processing and chemical analysis of food, soil, blood, stool, motor oil, semen, and other samples of interest.

Examples include microfluidic devices. Example microfluidic devices comprise a first microfluidic channel, a second microfluidic channel, and microfluidic output channel fluidly coupled to the first microfluidic channel and the second microfluidic channel via a fluid junction. The example device comprises a fluid actuator disposed in the microfluidic output channel to actuate to thereby pump a first fluid and a second fluid into the microfluidic output channel.

An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a valve including a valve housing and a valve structure located within the valve housing. The valve structure can be configured to permit fluid to flow through the valve when in an open position, and can include a gravity wall wherein, when the valve structure is in the open position, fluid moving through the valve structure moves upward against a force of gravity when travelling through the valve and traversing the gravity wall.