Provided is an analytical device including: a self-flowing microfluidic system, having a sample extraction location, at least one sample preparation location, and at least one sample analytical chamber; wherein the sample extraction location, the sample preparation location, and the at least one sample analytical chamber are interconnected by at least one microfluidic channel on a first substrate; and a signal readout system, having at least one sample analysis elements, and a data gathering and processing element.

There is disclosed a capillary microfluidic circuit including a main channel communicating with a flow inducing element. The main channel has intermediary inlets. Reservoirs for containing one or more liquids prior to being drawn into the main channel. The reservoirs include a first reservoir and at least a second reservoir. Each of the reservoirs has an upstream end connectable to vents for filling the reservoirs with the one or more liquids and a downstream end. The downstream end of each of the reservoirs is connected to the intermediary inlets of the main channel A conduit is disposed between the first reservoir and the a least a second reservoir. The conduit links the downstream end of the first reservoir with the upstream end of the at least a second reservoir.

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

Methods and devices for forming droplets are provided. In certain embodiments, the methods and devices form droplets having different diameters.

An anti-clogging microfluidic multichannel device comprising a first mixing chamber comprising a first and a second end, wherein the first end comprises at least one inlet connected in fluid communication with the first mixing chamber, and at least one first capillary element comprising a first and a second end, wherein the first end of the at least one first capillary element is connected in fluid communication with the second end of the first mixing chamber, at least one septum located within the at least one first capillary element, which divides the cross section of the at least one first capillary element in a plurality of channels, wherein the at least one first capillary element comprises a reduction of section along its longitudinal axis between a section of the at least one first capillary element and the second end of the at least one first capillary element. It is also described a microfluidics system and a method of production of emulsions using said microfluidics system.

An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. A mixing chamber can be located between the outlet port and both the first inlet port and second inlet port, the mixing chamber configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. An attachment structure can be located on the junction body and configured to attach the junction structure to the housing of the compounding device.

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

Conveying structure capable of increasing flow amount and flow speed of micro fluid includes: at least one rolling wheel base, disposed with a rotation power device and a rolling wheel having plural convex columns; a micro flow passage panel, disposed below the rolling wheel base and composed of a top cover panel and a bottom passage panel formed with at least two flow passages which are not in communication and formed with an inlet passage and an outlet passage; and at least one membrane, arranged above a circular recessed seat formed on the bottom passage panel and disposed with a convex ring having the interior formed with a hollow chamber, wherein through the convex columns of the rolling wheel base conveying a fluid in the hollow chamber with a peristaltic means, the fluid is enabled to flow from the inlet passage towards the outlet passage of the flow passages.

Methods and devices for forming droplets are provided. In certain embodiments, the methods and devices form droplets having different diameters.

A flow control and processing cartridge includes a cartridge body and a reaction chip. The cartridge body includes plural first chambers and plural first channels for storing and processing at least one of a sample, a reagent and a buffer and configured to perform nucleic acid extraction. The reaction chip is in conjunction with the cartridge body and includes plural second chambers and plural second channels configured to store and process an amplification reaction solution, and at least two fluidic networks configured to perform nucleic acid amplification and detection. One of the fluidic networks includes plural detection wells, a main fluid channel connected with the detection wells and configured to dispense the sample or control liquids into the detection wells, and a gas releasing channel connected with the detection wells and configured to release gas from the detection wells, wherein one of the fluidic networks is configured for quality control.