A system for use in combining two part preparations, such as bone cement, can include a chamber for intermixing liquid and powder components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement.

A vacuum mixing device for mixing PMMA bone cement from a monomer liquid and a cement powder, the vacuum mixing device comprising at least one cartridge comprising an evacuable interior for mixing of the bone cement, a mixing device for mixing the content in the interior of the at least one cartridge, which is arranged movably in the interior, a receptacle for receiving a separate container containing the monomer liquid or comprising an integrated container containing the monomer liquid, an opening device, which is arranged in the region of the receptacle in a manner movable relative to the receptacle so that, by moving the opening device, a separate container arranged in the receptacle is openable by means of the opening device, or the opening device is arranged in the region of the integrated container in a manner movable relative to the integrated container so that, by moving the opening device, the integrated container is openable by means of the opening device, a pump, in which a movable plunger for generating a negative pressure is arranged and delimits a pump chamber of the pump, and a connection line, which connects the interior of the at least one cartridge to the pump chamber of the pump, wherein the vacuum mixing system comprises an operating element that is operatable from outside, wherein the plunger in the pump is movable manually by means of the operating element, and wherein the opening device is movable relative to the receptacle or relative to the integrated container by means of the same operating element, and the mixing device in the interior of the cartridge is movable by means of the same operating element in order to mix the content in the interior of the cartridge.

An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing

The application relates to a vacuum mixing device for bone cement, where the monomer is pressed into a mixing container due to the surrounding vacuum and a gas volume present in the monomer container.

The invention provides an apparatus for generating mist, comprising: a container adapted to accommodate a liquid, the container comprising an inlet for receiving an incoming fluid stream into the container, and an outlet via which an outgoing fluid stream exits the container; at least one agitating means arranged in the container for agitating the accommodated liquid to generate droplets of the liquid; wherein the agitating means is arranged to be driven by the incoming fluid stream, such that the generated liquid droplets are caused by the incoming fluid stream to form the outgoing fluid stream, and subsequently, exit the container. The invention also provides a system for generating mist, comprising: a plurality of the above described apparatuses, comprising at least a first apparatus having a first inlet and a first outlet, and a second apparatus having a second inlet and a second outlet; wherein the first outlet is adapted to be connected with the second inlet to thereby allow fluid communication between the first apparatus and the second apparatus.

An assembly for preparing and dispensing a paste, preferably bone cement, includes a cylinder containing a powder and a receptacle containing a liquid. A piercing device is configured to open the receptacle to allow liquid to flow into the cylinder to be mixed with the powder. The receptacle is collapsed by a differential pressure between the cylinder and the receptacle.

A mixing device comprises a mixing space for mixing bone cement, at least one mixing element supported in the mixing space such that it can rotate, a gear for rotating the at least one mixing element, and at least one elastically deformable energy-storing element that is connected to the gear such that the gear can be driven by an elastic energy from the energy-storing element and such that the at least one mixing element can be rotated in the mixing space by means of the gear upon the release of elastic energy from the energy-storing element. Additionally, a vacuum mixing system and mixing method comprise the mixing device for mixing the bone cement.

A device (10), for receiving fluid, having a block (12) which comprises: a chamber (14) comprising a top and a bottom; and a chamber outlet (20) at the bottom of the chamber (14). The block (12) further comprises a magnetic stirrer (30) suspended in the chamber (14), wherein the magnetic stirrer (30) terminates above the bottom of the chamber (14), and is rotatably supported inside the chamber (14). The block (12) further comprises a microchannel (26) fluidly connected to the chamber (14) via the chamber outlet (20). The microchannel (26) may be fluidly connected to a downstream reservoir (24), and an upstream reservoir (22). The device (10) is suited for mixing a bead/cell suspension and an oil-based fluid in the microchannel (26) such that they form an emulsion which comprises a plurality of droplets, wherein at least one of the droplets encapsulates a bead/cell.

An apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial includes a vacuum device and a valve for withdrawing a gas from the particulate biomaterial and introducing the liquid biomaterial. The valve includes a hub, a valve body, a particulate port, a vacuum port, and a liquid port. The valve body selectively moves between first and second positions. The valve body at least partially defines a first passage and a second passage. The particulate port, the vacuum port, and the liquid port are each configured to fluidly connect to a particulate container, the vacuum device, and the liquid container, respectively. In the first position, the first passage fluidly connects the vacuum port to the particulate port for withdrawing the gas from the particulate container. In the second position, the second passage fluidly connects the liquid port to the particulate port for hydrating the particulate biomaterial.

A system for use in bone cement preparation can include a chamber for intermixing a liquid monomer and solid polymer components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The system can have a first interface disposed between the mixing chamber and the container and a second interface disposed between the mixing chamber and the vacuum channel. The second interface can to receive and position the filter between the mixing chamber and the vacuum channel. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement.