In some aspects, the present disclosure includes methods and systems for blending treatment fluids that include at least one of proppant or diverters for use in well treatment operations are provided. In one embodiment, the methods comprise receiving a base fluid, mixing an additive to a portion of the base fluid to form at least a portion of the well treatment fluid; and supplying the portion of the well treatment fluid to at least one or both of a first discharge pump selectively fluidically coupled to a mixer and a second discharge pump selectively fluidically coupled to the mixer. A plurality of valves are operated so as to select one of the first discharge pump and the second discharge pump to receive a flow of the portion of the well treatment fluid from the mixer.

A mixing applicator for mixing a fluid substance with a solid substance to obtain a resulting substance having a desired consistency, comprises: two valves slidably displaceable within a hollow elongated barrel and sequentially arranged along a longitudinal axis, the valves having a third cross-sectional shape being complementary to a first cross sectional shape, thereby providing fluid-tight engagement within the first cross-sectional shape, the third cross-sectional shape being mismatched with a second cross-sectional shape to form a mismatch zone along a length of a chamber, the mismatch zone allowing fluid flow around the valves, thereby to allow the two valves to effect mixing of the fluid substance with the solid substance and subsequently to remove excess fluid to obtain the resulting substance having the desired consistency.

Bone cement applicators and methods apply a bone cement dough in the region of the spine. The applicators and method have at least one tubular cartridge with an internal space, containing starting components of the bone cement, at least one dispensing plunger that is mobile in longitudinal direction on the inside of the at least one cartridge, a hose, an application opening through which the bone cement dough is applicable, a three-way valve being arranged in the hose or on a side of the hose facing the at least one cartridge and in fluid connection with the opening of the at least one cartridge and/or a collecting container arranged on the three-way valve for accommodation of bone cement dough. The three-way valve is appropriately designed and/or arranged in the bone cement applicator such that it, being in a first position, provides a fluid connection between the application opening and the opening of the at least one cartridge and closes a passage to the collecting container and, being in a second position, provides a fluid connection between the application opening and the collecting container and closes a passage to the opening of the at least one cartridge.

The present invention relates to a production module (1) for producing solid medicaments (22) in individual batches (37, 38, 39, 40), comprising a supplying device (2) for supplying powdered starting materials, a mixing device (3), which is connected to the feeding device (2) and is intended for working the supplied powdered starting materials into a product, a final working device (4), which is connected to the mixing device (3) and is intended for the final production of an end product from the worked starting materials, and a control device (5) for automatically controlling the supplying device (2) and the mixing device (3) and the final working device (4), characterized in that diverters (6, 7, 9, 12) allow a batch (37, 38, 39, 40) to be passed on from the supplying device (2) to the mixing device (3) and from the mixing device (3) to the final working device (4) without any backmixing, and in that data of all the process sensors and quality sensors of the production module (1) are linked with the respective batch (37, 38, 39, 40) by the control device (5), and in this way tracking and tracing of the batches is made possible.

A MEMS multiplexing system including: first and second fluid inputs; and a mixing network. The mixing network including: a first channel to receive the first fluid input; a second channel to receive the second fluid input; a multiplexing valve communicating with the first channel and the second channel, the multiplexing valve to cause the transport of the first fluid into the second channel so as to form a first interleaved fluid downstream from the multiplexing valve in the second channel and to cause the transport of the second fluid into the first channel so as to form a second interleaved fluid downstream from the multiplexing valve in the first channel; and the first channel and the second channel intersecting downstream from the valve so as to force mixing of the first interleaved fluid and the second interleaved fluid.

The present invention relates to a mixing apparatus. A production unit produces a working fluid that is in a supercritical state or a subcritical state. A storage unit stores a material. A dissolving unit dissolves the material in the working fluid. A mixer mixes the material together in the presence of the working fluid. A material feed valve opens or closes a flow passage through which the material is to pass to be fed from the storage unit into the dissolving unit. A working fluid inflow valve opens or closes a flow passage through which the working fluid is to pass to flow into the dissolving unit from the production unit. A mixer inflow valve opens or closes a flow passage through which the working fluid and the material are to pass to flow into the mixer from the dissolving unit.

Disclosed are devices and methods for synthesizing products. The disclosed devices and methods may be used to synthesize products, e.g., pharmaceutical or therapeutic compounds (i.e., drugs), ceramics, catalysts, biological polymers (i.e., proteins, enzymes), cells, tissues, or combinations thereof. The devices and methods may be operated in a microgravity environment.

The invention concerns a disposable container (1), intended to contain at least one liquid component to be sprayed and having a bottom (3), at least one peripheral side wall (2) extending from the bottom (3) to an open end spaced apart from and facing said bottom (3), which is provided with a closable vent device (6), characterised in that the closable vent device (6) comprises an aperture (7) forming an air passage, provided in the bottom, and a rotary valve (8) mounted on an outer surface (3a) of said bottom (3) in the extension of the aperture (7), in order to close and open the air passage.

A dispersing device includes: a casing having a liquid inlet; a rotating body accommodated in the casing and pivotably attached to a rotating shaft from one end of the rotating body; a liquid channel having, on the other end of the rotating body, a passage through which the liquid from the liquid inlet passes, and , inside the rotating body, a segment extended radially around the rotating shaft toward an outer side perpendicular to the rotating shaft and from the other end of the rotating body toward the one end of the rotating body in a direction of the rotating shaft axis and in which a cross section shape perpendicular to the rotating shaft is annular; and one connecting hole in the rotating body connecting the liquid channel with the exterior of the rotating body downstream of the liquid channel.

A main extruder and a side arm extruder are used in the extrusion of plastics with small amounts of additives or other small substances to be admixed. A minor portion of the plastic material is premixed with small quantity additive substances in a side arm extruder. The premixed material is discharged from the side arm extruder into the main extruder and there mixed with a major portion of feed material.