The present invention provides processes for preparation of substituted pyrazole compounds of formula II, that can be used as intermediates for preparation of substituted piperidine urea compounds useful for the treatment of dilated cardiomyopathy (DCM). R.sup.2 is independently selected from F, C1-C4 alkyl, C1-C4 haloalkyl, R.sup.3 is independently selected from H, F, C1-C4 alkyl, C1-C4 haloalkyl, R.sup.4 is C1-C4 alkyl, R.sup.6 is H or a protecting group and R.sup.7 is selected from H, CI or trialkylsilyl. ##STR00001##

A sorbent composition that is useful for injection into a flue gas stream of a coal burning furnace to efficiently remove mercury from the flue gas stream. The sorbent composition may include a sorbent with an associated ancillary catalyst component that is a catalytic metal, a precursor to a catalytic metal, a catalytic metal compound or a precursor to a catalytic metal compound. Alternatively, a catalytic metal or metal compound, or their precursors, may be admixed with the coal feedstock prior to or during combustion in the furnace, or may be independently injected into a flue gas stream. A catalytic promoter may also be used to enhance the performance of the catalytic metal or metal compound.

A sorbent composition that is useful for injection into a flue gas stream of a coal burning furnace to efficiently remove mercury from the flue gas stream. The sorbent composition may include a sorbent with an associated ancillary catalyst component that is a catalytic metal, a precursor to a catalytic metal, a catalytic metal compound or a precursor to a catalytic metal compound. Alternatively, a catalytic metal or metal compound, or their precursors, may be admixed with the coal feedstock prior to or during combustion in the furnace, or may be independently injected into a flue gas stream. A catalytic promoter may also be used to enhance the performance of the catalytic metal or metal compound.

A sorbent composition that is useful for injection into a flue gas stream of a coal burning furnace to efficiently remove mercury from the flue gas stream. The sorbent composition may include a sorbent with an associated ancillary catalyst component that is a catalytic metal, a precursor to a catalytic metal, a catalytic metal compound or a precursor to a catalytic metal compound. Alternatively, a catalytic metal or metal compound, or their precursors, may be admixed with the coal feedstock prior to or during combustion in the furnace, or may be independently injected into a flue gas stream. A catalytic promoter may also be used to enhance the performance of the catalytic metal or metal compound.

A sorbent composition that is useful for injection into a flue gas stream of a coal burning furnace to efficiently remove mercury from the flue gas stream. The sorbent composition may include a sorbent with an associated ancillary catalyst component that is a catalytic metal, a precursor to a catalytic metal, a catalytic metal compound or a precursor to a catalytic metal compound. Alternatively, a catalytic metal or metal compound, or their precursors, may be admixed with the coal feedstock prior to or during combustion in the furnace, or may be independently injected into a flue gas stream. A catalytic promoter may also be used to enhance the performance of the catalytic metal or metal compound.

It is disclosed a method of treating municipal and/or industrial sludge, comprising the steps of: a) providing the sludge, which has a pH of at least 6; b) adding a catalyst to the sludge; c) adding a radical initiator, selected from hydrogen peroxide and percompounds to the sludge; d) adding a polymer to the sludge to provide a chemically treated sludge; e) dewatering the chemically treated sludge in at least one stage to provide a dewatered sludge cake, wherein step b) and c) may be performed in any order.

It is disclosed a method of treating municipal and/or industrial sludge, comprising the steps of: a) providing the sludge, which has a pH of at least 6; b) adding a catalyst to the sludge; c) adding a radical initiator, selected from hydrogen peroxide and percompounds to the sludge; d) adding a polymer to the sludge to provide a chemically treated sludge; e) dewatering the chemically treated sludge in at least one stage to provide a dewatered sludge cake, wherein step b) and c) may be performed in any order.

The invention provides a direct solvent free method for the selective synthesis of trialkoxysilanes having the formula SiH(OR).sub.3, the method comprises providing a mixture of metallic silicon and copper based catalyst in a packed bed reactor, wherein neither the metallic silicon nor the silicon-catalyst mixture is subjected to any washing step. Claim 1 relates to a direct solvent free method for the selective synthesis of trialkoxysilanes having the formula SiH(OR).sub.3, wherein each R is a C.sub.1-C.sub.4 alkyl, the method comprising the steps of: providing a mixture of metallic silicon and copper based catalyst in a packed bed reactor; heating the mixture at an activation temperature of about 180 C.-about 250 C.; introducing C.sub.1-C.sub.4 alcohol to the reactor at a reaction temperature of about 180 C.-less than about 250 C.; condensing the reaction products in a heat exchanger; and collecting the condensed reaction products, wherein neither the metallic silicon nor the silicon-catalyst mixture is subjected to any washing step, including a hydro fluoric acid (HF) washing step.

An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses.

##STR00001##

An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses.

##STR00001##