A method for producing a catalyst composition for hydrogenation, wherein: (A): a titanocene compound represented by following general formula (1): ##STR00001## wherein R.sup.5 and R.sup.6 represent a group selected from the group consisting of hydrogen, a hydrocarbon group having 1 to 12 carbon atoms, an aryloxy group, an alkoxy group, a halogen group and a carbonyl group, and may be the same or different, and R.sup.1 and R.sup.2 represent a group selected from the group consisting of hydrogen and a hydrocarbon group having 1 to 12 carbon atoms, and may be the same or different, provided that R.sup.1 and R.sup.2 represent are not all hydrogens or all hydrocarbon groups having 1 to 12 carbon atoms; (B): a compound containing at least one element selected from the group consisting of elements Li, Na, K, Mg, Zn, Al, and Ca; and (C): an unsaturated compound
are used, and the method has: a force application step of applying a shearing force at a shearing rate of 1000 (1/s) or more to at least component (A); and a step of mixing components (A), (B), and (C).

Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Provided is a catalyst which comprises a compound represented by formula (1) and which exhibits activity for at least one type of reaction selected from among hydrosilylation reaction or hydrogenation reaction with respect to an aliphatic unsaturated bond and hydrosilane reduction reaction with respect to a carbon-oxygen unsaturated bond or a carbon-nitrogen unsaturated bond. Formula (1): M.sub.n(L.sub.m) {M represents Fe, Co, or Ni having an oxidation number of 0, L represents an isocyanide ligand represented by formula (2), n denotes an integer of 1-8, and m denotes an integer of 2-12. Formula (2): (CN).sub.xR.sup.1 (R.sup.1 represents a mono- to trivalent-organic group having 1-30 carbon atoms, optionally being substituted by a halogen atom, and optionally having interposed therein one or more atoms selected from among O, N, S, and Si; and x denotes an integer of 1-3)}.

The present invention pertains to a double metal cyanide complex catalyst having a moisture content of 8,000 to 140,000 ppm as determined by the Karl Fischer method, and having diffraction peaks at 2=36 and 2=47, but no diffraction peak at 2=34, in an X-ray diffraction pattern.

The invention relates to processes for the synthesis of 2-(3-cyano-5-fluorophenyl)-2-methylpropanoic acid and its use as intermediate in the preparation of GLP-1R/GIPR agonists. The invention also relates to a process of preparing a GLP-1R/GIPR agonist.