Water softening device includes water softening tank and neutralizing tank. Water softening tank softens raw water containing a hardness component by weakly acidic cation exchange resin. Water softening tank includes first water softening tank and second water softening tank. Neutralizing tank neutralizes the pH of softened water that has passed through water softening tank by weakly basic anion exchange resin. Neutralizing tank includes first neutralizing tank and second neutralizing tank. Water softening device is configured to cause raw water containing a hardness component to flow through first water softening tank, first neutralizing tank, second water softening tank, and second neutralizing tank in this order.

An ion exchange device main body 3 includes: a tubular body 31 into which an ion exchange resin bag 5 accommodating the ion exchange resin is inserted through an opening and which has a liquid outlet 312 in which a liquid outlet port 314 for discharging an ion exchange target liquid to outside is formed; a lid 32 that is supported by the tubular body 31 and has a gas injection portion 324 in which a gas injection port 325 for injecting a to an inside 311 of the tubular body 31 is formed; a lead-out pipe 42 that is connected to the liquid outlet 312 and guides the ion exchange target liquid to the outside; and a check valve 44 that is provided in the lead-out pipe 42 and prevents the ion exchange target liquid from flowing backward from the outside to the inside.

A purification method for an aqueous hydrogen peroxide solution includes subjecting the aqueous hydrogen peroxide solution to a reverse osmosis membrane separation treatment with a high-pressure reverse osmosis membrane separation device. The high-pressure reverse osmosis membrane has a denser skin layer on the membrane surface and is therefore lower in an amount of membrane permeate water per unit operating pressure but higher in the rejection rate of TOC and boron, as compared with a low-pressure or ultralow-pressure reverse osmosis membrane. The high-pressure reverse osmosis membrane permeate water is preferably further subjected to an ion exchange treatment with an ion exchange device including two or more columns packed with gel-type strong ion exchange resins.

A purification method for an aqueous hydrogen peroxide solution includes subjecting the aqueous hydrogen peroxide solution to a reverse osmosis membrane separation treatment with a high-pressure reverse osmosis membrane separation device. The high-pressure reverse osmosis membrane has a denser skin layer on the membrane surface and is therefore lower in an amount of membrane permeate water per unit operating pressure but higher in the rejection rate of TOC and boron, as compared with a low-pressure or ultralow-pressure reverse osmosis membrane. The high-pressure reverse osmosis membrane permeate water is preferably further subjected to an ion exchange treatment with an ion exchange device including two or more columns packed with gel-type strong ion exchange resins.

The present invention relates to purified antibody and antigen-binding fragment compositions that lack sulfated tyrosine on one or more tyrosine residues in the immunoglobulin chains. Purification methods for removing sulfated tyrosine variants from antibody and antigen-binding fragment compositions are also provided.

The present invention relates to purified antibody and antigen-binding fragment compositions that lack sulfated tyrosine on one or more tyrosine residues in the immunoglobulin chains. Purification methods for removing sulfated tyrosine variants from antibody and antigen-binding fragment compositions are also provided.

A surface treatment plant for treating objects, in particular vehicle bodies, has a thin film conversion process in which a ceramic thin film is applied to the objects using a process medium, a subsequent rinsing step in which the objects are rinsed with rinsing medium after the thin film conversion process, and a deionization plant which has a cation exchanger and a downstream anion exchanger and is configured for deionizing the process medium and/or the rinsing medium. For economical operation, the deionization plant is preceded by a preconditioning apparatus which is configured for removing complex anions which are formed and/or present in the thin film conversion process from the process medium and/or the rinsing medium. Furthermore, a corresponding preconditioning apparatus and a treatment process are described.

A surface treatment plant for treating objects, in particular vehicle bodies, has a thin film conversion process in which a ceramic thin film is applied to the objects using a process medium, a subsequent rinsing step in which the objects are rinsed with rinsing medium after the thin film conversion process, and a deionization plant which has a cation exchanger and a downstream anion exchanger and is configured for deionizing the process medium and/or the rinsing medium. For economical operation, the deionization plant is preceded by a preconditioning apparatus which is configured for removing complex anions which are formed and/or present in the thin film conversion process from the process medium and/or the rinsing medium. Furthermore, a corresponding preconditioning apparatus and a treatment process are described.

A method for producing a high-purity carboxylic acid ester, the method including bringing a crude carboxylic acid ester that contains anionic impurities and Ag, Al, Au, Ca, Cr, Cu, Fe, K, Mg, Na, Sn, and Zn metal impurities into contact with a cation-exchange resin, followed by bringing the crude carboxylic acid ester into contact with an anion-exchange resin to obtain to provide a high-purity carboxylic acid ester in which the Ag, Al, Au, Ca, Cr, Cu, Fe, K, Mg, Na, Sn, and Zn metal impurity content are each less than 1 ppb and the anionic impurity content is less than 1 ppm.

A method for producing a high-purity carboxylic acid ester, the method including bringing a crude carboxylic acid ester that contains anionic impurities and Ag, Al, Au, Ca, Cr, Cu, Fe, K, Mg, Na, Sn, and Zn metal impurities into contact with a cation-exchange resin, followed by bringing the crude carboxylic acid ester into contact with an anion-exchange resin to obtain to provide a high-purity carboxylic acid ester in which the Ag, Al, Au, Ca, Cr, Cu, Fe, K, Mg, Na, Sn, and Zn metal impurity content are each less than 1 ppb and the anionic impurity content is less than 1 ppm.