A moisture control apparatus includes at least one electrode configured to receive at least one of an alternating current or a direct current, and to direct at least one of an electric field, a magnetic field, an electromagnetic field, an electromagnetic wave, a sonic wave, or a supersonic wave toward a substance. The moisture control apparatus further includes a controller configured to communicate with the at least one electrode, wherein the controller is configured to control a voltage applied to the at least one electrode to induce a bonded state between water molecules of moisture present in the substance.

A moisture control apparatus includes at least one electrode configured to receive at least one of an alternating current or a direct current, and to direct at least one of an electric field, a magnetic field, an electromagnetic field, an electromagnetic wave, a sonic wave, or a supersonic wave toward a substance. The moisture control apparatus further includes a controller configured to communicate with the at least one electrode, wherein the controller is configured to control a voltage applied to the at least one electrode to induce a bonded state between water molecules of moisture present in the substance.

A moisture control apparatus includes at least one electrode configured to receive at least one of an alternating current or a direct current, and to direct at least one of an electric field, a magnetic field, an electromagnetic field, an electromagnetic wave, a sonic wave, or a supersonic wave toward a substance. The moisture control apparatus further includes a controller configured to communicate with the at least one electrode, wherein the controller is configured to control a voltage applied to the at least one electrode to induce a bonded state between water molecules of moisture present in the substance.

A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.

Apparatus and methods for using a flow cell array are provided herein. An apparatus includes an array comprising one or more pixels, wherein each of the one or more pixels comprises multiple reaction sites openings; a first set of one or more sub-surface channels, wherein each of the multiple reaction site openings is connected to a sub-surface channel from the first set of one or more sub-surface channels; a second set of two or more sub-surface channels; and multiple vias connecting each channel from the first set of one or more sub-surface channels to (i) a first sub-surface channel from the second set of two or more sub-surface channels and (ii) a second sub-surface channel from the second set of two or more sub-surface channels.

Apparatus and methods for using a flow cell array are provided herein. A method includes determining placement of one or more reaction sites on a first component; providing a material for the one or more reaction sites in one or more surface channels of the first component; connecting the first component to a second component to form an array, wherein the one or more surface channels of the first component connect the one or more reaction sites with one or more vias, and wherein the second component comprises the one or more vias connected to multiple sub-surface channels; and aligning the one or more surface channels of the first component with the one or more vias of the second component to form a connection between the first component and the second component.

The present invention provides improved automated systems and methods for synthesis of biopolymers including DNA and RNA. The automated systems and methods represent a number of improvements over existing systems for multiplex synthesis of biopolymers in a combinatorial fashion.

A method includes forming a composition of matter including an amount of a reporter compound, a binding member capable of capturing the reporter compound, and an amount of a target nucleic acid capable of forming complexes with the reporter compound.

The invention provides a method for lysing a single cell embedded in a tissue from the inside of the cell, and collecting the intracellular lysate for use in analytical methods. This method preserves the state of molecules of the cell, and therefore allows for transformation of a single target cell in live tissue into a format that can be evaluated using analytical methods.

The present invention provides a system for performing reactions, where the system comprises a plurality of synthesisers that are in communication via a communal reporting platform. A synthesiser is programmed for the automated synthesis of one or more chemical or biological reactions, and the synthesiser comprises a reaction vessel which is supplied by a reagent delivery system, an analytical system for analysing a reaction, and a controller for managing the reagent delivery system and the analytical system, and for communication with the reporting platform. Also provided are methods for performing a plurality or reactions using the system.