A flow reactor [10] includes a fluidic module [20] having an external surface [22], an internal process fluid path [24], and an input port [I] and an output port [O] connected to the process fluid path [24]. An upstream coupler [30] is connected to the input port [I], and a downstream coupler [40] is connected to the output port [O]. The upstream coupler [30] has a gasket [38] in a gasket groove [36] pressed against the fluidic module [22] and a hollow circular cylindrical post [35] protruding from the upstream coupler [32] and extending into the input port [I]. The downstream coupler [40] has a gasket [48] in a gasket groove [46] pressed against the fluidic module [20] and no hollow circular cylindrical post extending into the output port [O].

A microfluidic device for performing physical, chemical or biological treatment to at least one packet without contamination.

A microfluidic device for performing physical, chemical or biological treatment to at least one packet without contamination.

A method of forming complex structures in a ceramic-, glass- or glass-ceramic-body microfluidic module is disclosed including the steps of providing at green-state refractory-material structure comprising least a portion of a body of a microfluidic module, providing a removeable insert formed of a carbon or of a carbonaceous material having an external surface comprising a negative surface of a desired surface to be formed in the microfluidic module, machining an opening in the green-state structure, positioning the insert in the opening, firing the green-state structure and the insert together, and after firing is complete, removing the insert. The insert is desirably a screw or screw shape, such that interior threads are formed thereby. The insert desirably comprises graphite, and the structure desirably comprises ceramic, desirably silicon carbide.

A micro-channel reaction apparatus includes a first mixing device and a first jetting device. The first mixing device includes a first inflow channel and a second inflow channel respectively used to direct a first fluid and a second fluid into the micro-channel reaction apparatus. The first jetting device includes a first tapering portion and a first flared portion, wherein one end of the first tapering portion is connected to the first inflow channel and the second inflow channel; another end of the first tapering portion is connected to the first flared portion; and the first tapering portion has a contract ratio of inner diameter ranging from 0.1 to 0.75.

The invention providing methods of loading and unloading particulate from micorchannels in apparatus that contains multiple microchannels, typically apparatus that is designed to operate with hundreds or thousands of particulate-containing microchannels. Aligning a sonicating head at one end of a set of microchannels provides a particularly effective mode for densifying particulate in microchannels.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

The present disclosure discloses a method for synthesizing quinolones intermediates by a continuous flow reaction. Specifically, according to the method, a microchannel reactor is used, which improves the selectivity and conversion rate of the reaction, and the conversion rate of compound ii is increased to more than 95% and the yield is increased to more than 85%; avoids the use of a solvent such as methanol, and methyl tert-butyl ether, etc., in the intermittent reaction process, which simplifies the post-processing method, shortens the overall operation time from about 24 hours to a few minutes, greatly improving the production efficiency, and realizing the continuity and automation of the whole process; and thus makes the product have high purity and high yield, which is suitable for industrial production.

An apparatus includes a substrate having a recess and a multitude of particles arranged in the recess. A first portion of the particles is joined to a porous structure by means of a coating. A second portion of the particles is not joined by means of the coating. The first portion of the particles is arranged closer to an opening of the recess than the second portion of the particles so that a leaking of the second portion of the particles from the recess through the opening is prevented.

A photovoltaic apparatus comprising: at least one photovoltaic surface electrically connected to a set of photovoltaic electrodes; and a chemical reactor electrically connected to the set of photovoltaic electrodes. The chemical reactor enables N pairwise fluid contacts among k chemical fluids, with k2 and N4 and comprises: a reaction layer extending in a plane subtended by two directions; N chemical cells, each including two circuit portions, designed for enabling circulation of two of the k chemical fluids, respectively, the two circuit portions intersecting each other, thereby enabling one pairwise fluid contact for the two of the k chemical fluids; and a fluid distribution circuit comprising: k sets of inlet orifices sequentially alternating along lines parallel to one of the two directions; and k sets of outlet orifices sequentially alternating along lines parallel to the inlet orifices, and wherein, each circuit portion connects an inlet orifice to an outlet orifice.