A plate-type flow reactor device with a first plate (20) having first and second opposing surfaces (22, 24) and one or more through-holes (26); a second plate sealed against the first surface (22) by at least two first O-rings (50); a third plate (40) sealed against the second surface (24) by at least one second O-ring (60); two or more first elongated channels (70) defined between the first surface (22) and the second plate and one or more second elongated channels (80) defined between the second surface (24) and the third plate, wherein each first channel communicates with the at least one second channel (80) via one or more of the through-holes (26) through the first plate (20), and said one first channel (70a) communicates with another first channel (70b) of the two or more first channels (70) only via said at least one second channel (80), and each first channel (70) is individually surrounded by at least one of the first O-rings (50) and the at least one second is individually surrounded by the at least one second O-ring (60).

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A test method and test apparatus is provided that employs a microfluidic device to characterize properties of a fluid. The microfluidic device has a first inlet port, an outlet port, and a microchannel as part of a fluid path between the first inlet port and the outlet port. While generating a flow of the fluid through the microchannel of the microfluidic device, fluid pressure at the first inlet port of the microfluidic device is measured and recorded in conjunction with varying the controlled temperature of the microchannel of the microfluidic device to characterize the properties of the fluid that flows through the microchannel of the microfluidic device. The properties of the fluid can relate to the clathrate hydrate formation condition of the fluid at the pressure of the flow through the microchannel of the microfluidic device.

The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.

The present invention relates to a process for an epimerization of a saccharide in a microdevice consisting of a network of micron-sized channels in presence of molybdenum containing catalyst. It further relates to the use of a microdevice consisting of a network of micron-sized channels for the epimerization reaction of saccharides and the oligomerization of the thus obtained epimerized saccharide, preferably into manno-oligosaccharides.

The invention discloses a glass lined metal micro-reactor with enhanced heat transfer efficiency in continuous flow operation. More particularly, the invention discloses a glass lined micro-reactor that can be reassembled. The invention provides a novel glass lined metal micro-reactor with micro fluidic channels that provide a better mixing, better heat exchange, and better temperature control. The micro fluidic channels machined in the glass lined metal reactor/mixer may be straight, curved, lamellar, flower shaped, or spiral such that the cross sectional area of the micro fluidic channel is configured to suit the cross sectional area of the micro-reactor.

The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel

An apparatus for manufacturing a quantum dot is provided, the apparatus including a first supplying part that provides a cationic precursor, a second supplying part that provides an anionic precursor, a mixing part connected to the first supplying part and the second supplying part, and a reaction part including a reaction tube configured to receive a liquid mixture of the cationic precursor and the anionic precursor from the mixing part and a first microwave generator configured to provide a microwave that is transmitted through the reaction tube. Therefore, the apparatus may produce a quantum dot of multi-element compounds.

A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.